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Updated: Jul 9, 2025

Genome-wide Gene Deletions in Streptococcus sanguinis by High Throughput PCR
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Genome-wide Gene Deletions in Streptococcus sanguinis by High Throughput PCR

Published on: November 23, 2012

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一种新型的侵入性Streptococcus pyogenes变异亚系,通过对emm12基因组区域的重组替换获得

Yvette Unoarumhi1, Morgan L Davis1, Lori A Rowe1

  • 1Centers for Disease Control and Prevention, Biotechnology Core Facility Branch, National Center for Emerging and Zoonotic Infectious Diseases, Division Scientific Resources, Atlanta, GA, USA.

Scientific reports
|December 6, 2023
PubMed
概括

甲组链球菌 (GAS) 可以通过重组获得新的M蛋白基因类型. 研究人员发现了一种新的GAS变种 (emm82/ST36),该变种从emm模式A切换到E,显示多样性增加和抗生素耐药性.

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相关概念视频

Viral Recombination00:57

Viral Recombination

Cells are sometimes infected by more than one virus at once. When two viruses disassemble to expose their genomes for replication in the same cell, similar regions of their genomes can pair together and exchange sequences in a process called recombination. Alternatively, viruses with segmented genomes can swap segments in a process called reassortment.
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Conservative Site-specific Recombination and Phase Variation

Because the DNA segments are cut and reorganized in a direction-specific manner, site-specific recombination has emerged as an efficient genetic engineering technique. Flippase and Cyclization recombinases or Flp and Cre, respectively, are two members of the tyrosine recombinase family derived from bacteriophages, that are used to mediate site-specific DNA insertions, deletions, and targeted expression of proteins in mammalian cell lines.
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Exon Recombination

The evolution of new genes is critical for speciation. Exon recombination, also known as exon shuffling or domain shuffling, is an important means of new gene formation. It is observed across vertebrates, invertebrates, and in some plants such as potatoes and sunflowers. During exon recombination, exons from the same or different genes recombine and produce new exon-intron combinations, which might evolve into new genes. 
Exon shuffling follows “splice frame rules.” Each exon...
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