在四肢的个体中,通过穿皮脊柱刺激来表征神经状态
Jeonghoon Oh1, Michelle S Scheffler1, Catherine A Martin1
1Department of Neurosurgery, Center for Translational Neural Prosthetics and Interfaces, Center for Neuroregeneration, Houston Methodist Research Institute, Houston, TX, 77030, USA.
Scientific reports
|December 6, 2023
概括
穿皮脊柱刺激 (TSS) 显示,在脊髓损伤 (SCI) 后,上肢运动池的招募发生了变化. 来自TSS的电生理学数据提供了对SCI患者的功能不对称性和神经通路中断的见解.
科学领域:
- 神经科学是一个神经科学.
- 临床电生理学 临床电生理学
- 康复医学 康复医学 康复医学
背景情况:
- 穿皮脊髓刺激 (TSS) 是一种评估脊髓功能的新兴技术.
- 脊髓损伤 (SCI) 往往导致复杂的神经缺陷,影响上肢 (UL) 功能.
- 了解UL机动车队的招聘模式对于SCI后的康复至关重要.
研究的目的:
- 为了研究上肢 (UL) 动力池的招募模式,使用跨皮脊柱刺激 (TSS) 在脊柱损伤的上下.
- 探索UL机动车池招募模式与宫SCI患者的神经/功能状态之间的关系.
- 评估TSS衍生的电生理学数据在表征SCI相关功能障碍方面的有用性.
主要方法:
- 在八名因宫SCI而患有四肢的参与者中,TSS应用于宫脊髓 (C3-C4和C7-T1水平).
- 在UL肌肉中记录和分析了脊柱唤起的运动潜力 (SEMPs).
- 电生理学反应是通过SCI水平以上和以下的动力池内化肌肉之间的比较.
- 数据与参与者的神经和功能状态相关联.
主要成果:
- 在SCI水平以下的运动池内的UL肌肉与损伤以上的肌肉相比,对TSS的敏感性降低.
- 在大多数肌肉中,招募模式是不对称的,并且根据SCI水平,程度和侧面而异.
- 电生理学发现与UL功能不对称性和神经通路中断相关.
结论:
- 来自TSS的电生理学数据为UL功能不对称性和SCI后的运动控制变化提供了宝贵的见解.
- TSS可以补充临床和功能评估,提供对残留运动功能的更深入的理解.
- 这种技术有望改善SCI患者的评估和管理.
相关概念视频
Somatosensation
The somatosensory system relays sensory information from the skin, mucous membranes, limbs, and joints. Somatosensation is more familiarly known as the sense of touch. A typical somatosensory pathway includes three types of long neurons: primary, secondary, and tertiary. Primary neurons have cell bodies located near the spinal cord in groups of neurons called dorsal root ganglia. The sensory neurons of ganglia innervate designated areas of skin called dermatomes.
The Spinal Cord
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Nutrient Artery
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Sensory Information Processing
Sensory information processing begins at the sensory receptors located in the skin and other tissues, which detect somatic sensory stimuli such as touch, temperature, or pain. These receptors function as catalysts, initiating...
Sensory Information Processing
Sensory information processing begins at the sensory receptors located in the skin and other tissues, which detect somatic sensory stimuli such as touch, temperature, or pain. These receptors function as catalysts, initiating...
Major Somatic Sensory Pathways
Sensory impulses related to touch, pressure, vibration, and proprioception from various body parts, such as the limbs, trunk, neck, and posterior head, travel to the cerebral cortex through the posterior column-medial lemniscus pathway. The pathway’s name derives from the two white-matter tracts that convey the impulses: the spinal cord's posterior column and the brainstem's medial lemniscus. First-order sensory neurons extend their axons into the spinal cord, forming the posterior columns...
Spinal Cord
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