孕产妇免疫因子在脑发育神经免疫学中的作用
Mehdi Mohebalizadeh1,2,3, Golsa Babapour1, Mahdi Maleki Aghdam1,2
1Student Research Committee, Urmia University of Medical Sciences, Urmia, Iran.
Molecular neurobiology
|December 6, 2023
概括
怀孕期间的孕产妇免疫激活 (MIA),通常来自感染,可能会影响胎儿的大脑发育. 本综述探讨了MIA如何影响神经发育过程和疾病.
科学领域:
- 神经科学是一个神经科学.
- 免疫学 免疫学 免疫学
- 发展生物学 发展生物学
背景情况:
- 怀孕期间的孕产妇免疫激活 (MIA) 涉及影响胎儿发育的复杂相互作用.
- 多种因素可以引发MIA,其中主要关注的是孕产妇感染.
- 胎儿大脑特别容易受到母亲炎症的影响.
研究的目的:
- 审查MIA影响胎儿大脑发育的机制.
- 探索怀孕期间母亲感染和神经发育疾病之间的联系.
- 突出免疫媒介在调解这些影响中的作用.
主要方法:
- 对调查MIA和神经发育的研究进行文献综述.
- 分析母亲抗体,细胞因子,化学因子和质细胞的作用.
- 检查特定的病毒感染及其与神经发育结果的关联.
主要成果:
- MIA通过抗体,细胞因子,化学因子和微质细胞影响胎儿的神经发育.
- 孕产妇感染,包括寨卡病毒,CMV,甲型流感和SARS-CoV-2,与神经发育的改变有关.
- 这些感染可以增加患精神分裂症和自闭症等疾病的风险.
结论:
- 怀孕期间母亲感染是MIA的一个关键因素.
- MIA对胎儿大脑发育和神经发育障碍的风险有重大影响.
- 了解这些途径对于潜在的干预至关重要.
更多相关视频
09:09Generating a Reproducible Model of Mid-Gestational Maternal Immune Activation using PolyI:C to Study Susceptibility and Resilience in Offspring
Published on: August 17, 2022
1.7K
08:50A Murine Model of Fetal Exposure to Maternal Inflammation to Study the Effects of Acute Chorioamnionitis on Newborn Intestinal Development
Published on: June 24, 2020
3.8K
相关概念视频
01:22Development of Immunocompetence
315
The initiation of cell-mediated immunity can be observed as early as the third month of fetal growth, with active antibody-mediated immunity following approximately one month later.
The initial cells that migrate from the fetal thymus settle within the skin and epithelial tissues lining the mouth, digestive tract, and in females, the uterus and vagina. These cells, including skin-based dendritic cells, serve as antigen-presenting cells, playing a key role in T cell activation.
Subsequent T...
The initial cells that migrate from the fetal thymus settle within the skin and epithelial tissues lining the mouth, digestive tract, and in females, the uterus and vagina. These cells, including skin-based dendritic cells, serve as antigen-presenting cells, playing a key role in T cell activation.
Subsequent T...
315
01:31Neurotransmitters
965
Neurotransmitters are essential chemical messengers within the nervous system, facilitating the communication between neurons. These chemical messengers, varying in function and effect, are critical for sustaining various aspects of neurological health and emotional well-being.
965