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Updated: Jul 9, 2025

Dual DNA Rulers to Study the Mechanism of Ribosome Translocation with Single-Nucleotide Resolution
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Published on: July 8, 2019

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mRNA的N1-甲基伪化导致了+1的核糖体框架转移

Thomas E Mulroney1, Tuija Pöyry1, Juan Carlos Yam-Puc1

  • 1MRC Toxicology Unit, University of Cambridge, Cambridge, UK.

Nature
|December 6, 2023
PubMed
概括

修改后的mRNA疫苗,如SARS-CoV-2疫苗,可能会因N1-甲基伪氨酸而导致核糖体框架转移. 序列优化可以减少这些意外的蛋白质产物.

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