减少NK细胞数量是COVID-19儿童发作的高风险因素
Ting Shi1, Yuanxi Bian1, Jiahui Wu1
1Department of Infectious Diseases & Pediatric Intensive Care Unit, Children's Hospital of Soochow University, 303 Jingde Road, Suzhou, 215000, Jiangsu, China.
患有COVID-19并经历的儿童可能有发烧性史或减少自然杀手 (NK) 细胞数. 这些因素显著增加了患有病毒的儿科患者发作的风险.
科学领域:
- 儿科神经学 儿科神经学
- 传染性疾病 传染性疾病
- 免疫学 免疫学 免疫学
背景情况:
- 包括在内的神经症状是COVID-19儿童日益关注的问题.
- 儿童COVID-19病例中的发作对身体和精神健康构成重大风险.
- 识别这些神经症状的危险因素对于及时干预至关重要.
研究的目的:
- 调查COVID-19诊断的儿童中发作的特定风险因素.
- 分析临床和实验室数据,以了解这一群体中发作的预测因素.
主要方法:
- 一项前性研究涉及102名的COVID-19患者,172名没有的COVID-19患者和50名健康对照.
- 对临床特征和实验室参数的分析,包括完整血细胞计数和淋巴细胞子集.
- 多变量回归分析以确定独立的风险因素.
主要成果:
- 在37.2%的儿科COVID-19病例中观察到,主要是患有Omicron变种的1-3岁儿童.
- 在组中发现了中性粒细胞与淋巴细胞的比率 (NLR),单细胞与淋巴细胞的比率 (MLR) 和血小板与淋巴细胞的比率 (PLR) 的升高.
- 在患有COVID-19相关的儿童中,发现淋巴细胞,乙氨基,血小板和NK细胞的数量显著降低.
结论:
- 发烧发作史是COVID-19儿童发作的重要独立风险因素.
- 减少自然杀手 (NK) 细胞数被确定为儿童患者COVID-19相关的另一个关键风险因素.
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