相关实验视频

Updated: Jul 9, 2025

OP-IVM: Combining In vitro Maturation after Oocyte Retrieval with Gynecological Surgery

OP-IVM: Combining In vitro Maturation after Oocyte Retrieval with Gynecological Surgery

Published on: May 9, 2021

添加hMG会影响试管婴儿刺激期间的孕激素水平变化和LBR:一项回顾性队列研究

Victoria G Wesevich¹, Serin I Seckin², Dawn A Kelk³

¹Division of Reproductive Endocrinology and Infertility Department Obstetrics, Gynecology and the Reproductive Sciences, Yale University School of Medicine, 333 Cedar Street, P.O.Box 208063, New Haven, CT, 06520, USA. victoria.wesevich@yale.edu.

Reproductive biology and endocrinology : RB&E

|December 7, 2023

概括

试管婴儿期间孕激素水平 (ΔP) 的变化预测了怀孕的成功. 最佳的 ΔP (0.7-0.85 ng/mL) 和淋巴激素比率 (hMG:rFSH 0.3-0.6) 可以改善新鲜胚胎移植中的临床怀孕和活产率.

科学领域:

生殖内分泌学生殖内分泌学
在体外受精 (IVF)

背景情况:

在试管婴儿刺激期间早产孕激素 (P) 升高会对子宫内膜受容性和怀孕率产生负面影响.
这种增长影响了关于新鲜与冷胚胎移植 (ET) 的决定.

研究的目的:

为了确定从基线到触发的孕激素水平 (ΔP) 的变化是否可预测新鲜ET后怀孕的结果.
调查性腺激素比率是否影响孕激素的上升,从而影响临床妊娠率 (CPR) 和活产率 (LBR).

主要方法:

对291名经过受控卵巢高刺激-IVF (COH-IVF) 后接受新鲜ET的患者进行了回顾性队列研究.
对峰值P,ΔP和hMG:rFSH比率与CPR和LBR相关的分析.
多变量后勤建模,以评估P水平和淋巴激素比率的预测值.

主要成果:

ΔP与心肺复苏相关;0.7-0.85 ng/mL的范围是最具预测性 (88.9%的心肺复苏).
妊娠结果的最佳峰值P范围是0.15-1.349 ng/mL.
ΔP与CPR/LBR的关联比峰值P更强.
一个hMG:rFSH比率>0.6预测较低的峰值P和较小的ΔP.
观察到最高的CPR (75.6%) 和LBR (55.4%) 的hMG:rFSH比分分别为0.3-0.4和0.3-0.6.

结论:

ΔP是怀孕率的有价值预测指标,有助于临床决定新的ET时间.
优化性腺激素比率 (hMG:rFSH) 可以最大限度地降低孕激素的升高,并增强CPR/LBR.
化激素 (LH) 的活性在COH-IVF周期中至关重要.

关键词:

控制的卵巢刺激控制的卵巢刺激它们是淋巴激素 (Gonadotropins).孕激素的峰值就是孕激素的峰值.

更多相关视频

Author Spotlight: Advancing Therapeutic Strategies for Improving Pregnancy Rates by Analyzing Embryo-Endometrium Interactions

Author Spotlight: Advancing Therapeutic Strategies for Improving Pregnancy Rates by Analyzing Embryo-Endometrium Interactions

Published on: June 21, 2024

Modified MicroSecure Vitrification: A Safe, Simple and Highly Effective Cryopreservation Procedure for Human Blastocysts

Modified MicroSecure Vitrification: A Safe, Simple and Highly Effective Cryopreservation Procedure for Human Blastocysts

Published on: March 2, 2017

相关概念视频

In Vitro Fertilization

In Vitro Fertilization

In vitro fertilization (IVF) is a form of assisted reproductive technology where an egg is fertilized with sperm in a controlled laboratory environment before transferring the resulting embryo into the uterus. This process is designed to help individuals and couples experiencing difficulties conceiving.
The IVF process begins with ovarian stimulation, during which reproductive endocrinologists prescribe hormonal medications to stimulate the ovaries to produce multiple eggs instead of the single...

Ovarian Cycle

Ovarian Cycle

The menstrual cycle includes a critical component known as the ovarian cycle, which undergoes two main phases each month—the follicular phase and the luteal phase. The follicular phase is variable and averaging around 14 days. Ovulation, triggered by a surge in luteinizing hormone (LH), marks the transition between the two phases. The second phase, the luteal phase, is relatively consistent, lasting approximately 14 days, and is marked by the activity of the corpus luteum. While a cycle...

Hormonal Regulation of the Menstrual Cycle

Hormonal Regulation of the Menstrual Cycle

The ovarian cycle regulates endometrial changes throughout a single menstrual cycle via the coordinated action of gonadotrophin-releasing hormone (GnRH) and gonadotrophins.
At puberty, GnRH begins a pulsatile release pattern, which triggers the anterior pituitary gland to secrete follicle-stimulating hormone (FSH) and luteinizing hormone (LH). The frequency and amplitude of GnRH pulses vary across the menstrual cycle, with faster pulses favoring LH release and slower pulses favoring FSH...