凝血参数与脊椎骨折患者在外科手术期间发生静脉血栓栓塞的发生有关
1Department of Orthopedics, Dongzhimen Hospital, Beijing University of Traditional Chinese Medicine, No. 5 Haihai Warehouse, Dongzhimen, Beijing, 100000, China.
Journal of orthopaedic surgery and research
|December 7, 2023
概括
凝血标志物,如D-二聚合物,纤维素和纤维素降解产物,以及年龄,脊髓损伤和延迟手术,可以预测脊髓手术患者的静脉血栓塞栓症 (VTE).
科学领域:
- 医学研究 医学研究
- 临床医学 临床医学
- 血栓形成研究研究
背景情况:
- 静脉血栓塞栓症 (VTE) 是住院患者死亡的重要原因.
- 在脊柱外科手术患者中,VTE的预测标志物仍在研究中.
研究的目的:
- 确定与凝血相关的参数和预测脊髓损伤手术患者中静脉瘤发生的临床因素.
主要方法:
- 对符合纳入标准的脊柱骨折患者的回顾性分析.
- 凝血参数的评估:激活的部分血栓塑时间,前血时间,血时间,D-二聚合物 (D-D),纤维素 (FIB) 和纤维素降解产物 (FDP).
- 应用接收器操作特征 (ROC) 和危险比率 (HR) 分析来评估相关性.
主要成果:
- 在VTE患者中,D-二聚合物,纤维素和FDP水平显著更高.
- 多变量分析确定了六个危险因素:年龄≥60岁,脊髓损伤,术后睡眠时间≥5天,D-二次数≥0.54 mg/L,纤维素≥3.75 g/L,FDP≥5.19 mg/L.
结论:
- 年龄,脊髓损伤,术后恢复延迟,以及D-二次体,纤维素和FDP水平升高是脊髓外科手术患者静脉瘤的显著预测因素.
相关概念视频
01:24Disorders of Hemostasis
926
Hemostasis, the process that stops bleeding after a blood vessel injury, is crucial for maintaining the integrity of the circulatory system. However, disorders of hemostasis can disrupt this delicate balance, leading to either excessive clotting or bleeding. These disorders can be broadly classified into thromboembolic disorders and bleeding disorders.
Thromboembolic Disorders
Two factors primarily cause thromboembolic conditions.
Thromboembolic Disorders
Two factors primarily cause thromboembolic conditions.
926
01:30Anticoagulant Drugs: Low-Molecular-Weight Heparins
711
Hemostasis is a crucial process that prevents excessive blood loss from damaged blood vessels. It involves various mechanisms such as vasoconstriction, platelet adhesion and activation, and fibrin formation. The importance of each mechanism depends on the type of vessel injury. In contrast, thrombosis is the abnormal formation of a blood clot within the blood vessels, leading to potential complications if the clot obstructs blood flow. Thrombosis can be caused by increased coagulability of the...
711
01:20Extrinsic and Intrinsic Pathways of Hemostasis
7.9K
Blood clotting or coagulation involves extrinsic and intrinsic pathways, which ultimately merge into the common pathway, forming a fibrin clot.
The Extrinsic Pathway
The extrinsic pathway of coagulation is typically initiated by tissue damage that exposes blood to tissue factor (TF), a protein released by the damaged tissue cells outside the blood vessels—this interaction with TF triggers biochemical reactions involving specific clotting factors. The key player here is Factor VII, which...
The Extrinsic Pathway
The extrinsic pathway of coagulation is typically initiated by tissue damage that exposes blood to tissue factor (TF), a protein released by the damaged tissue cells outside the blood vessels—this interaction with TF triggers biochemical reactions involving specific clotting factors. The key player here is Factor VII, which...
7.9K