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控制卵巢刺激方案与植入前遗传测试中卵巢胚胎细胞的比率之间的相关性,以检测卵巢细胞的周期

Bixia Huang^1,2, Hui Li^1,2, Bin Xu^1,2

¹Reproductive Medicine Center, Xiangya Hospital of Central South University, Changsha, China.

Reproductive biology and endocrinology : RB&E

|December 7, 2023

概括

对于受控卵巢刺激 (COS),GnRH-ant协议在植入前遗传测试中最有效,以检测阳积分 (PGT-A) 周期,导致与PPOS协议相比较高的阳积分囊细胞率. 这凸显了在辅助生殖技术中需要个性化的COS策略.

科学领域:

生殖内分泌学生殖内分泌学
辅助生殖技术 (ART) 是一种辅助生殖技术.

背景情况:

关于哪个受控卵巢刺激 (COS) 协议最大限度地提高了胚胎细胞化率,存在不一致的发现.
植入前遗传测试 (PGT-A) 对于改善ART成功至关重要.

研究的目的:

为了研究不同COS协议 (GnRH-a,GnRH-ant,PPOS) 与PGT-A周期中的欧囊胚胎细胞率之间的关联.
确定最有效的COS协议,以优化PGT-A结果.

主要方法:

在三个生殖医学中心 (2019年1月至2022年8月) 进行了457次PGT-A周期的回顾性分析.
对PPOS,GnRH-agonist (GnRH-a) 和GnRH-ant协议进行比较.
收集的数据包括患者人口统计,COS协议和胚胎结局.

主要成果:

在协议组之间没有观察到基线特征 (BMI,不孕症类型/持续时间) 的显著差异.
与GnRH-a和GnRH-ant协议相比,PPOS协议导致平均euploid芽细胞显著降低,并且每次活检,每次检索卵细胞和每次MII卵细胞的euploidy率更低.
回归分析表明,GnRH-ant协议与欧囊胚胎的发育率和数量有积极的关联,而GnRH-a与PPOS相比没有显著的关联.

结论:

在PGT-A周期中,GnRH-ant协议表现出卓越的疗效,与更高的euploid母细胞瘤率相关.
研究结果表明,个性化的COS策略对于优化ART的结果至关重要.
进一步的研究可能会探索GnRH-a协议和其他影响euploidy的因素的细微差别.

关键词:

形积分症 (Aneuploidy) 是一种无形积分症.控制的卵巢刺激控制的卵巢刺激欧类胚胎细胞是什么?在植入前进行遗传检测.

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