在全身低血压期间维持大脑输液的机制在老年人中受损
Kulsum Abdali1, Xiaoan Chen1,2, Sarah Ross3
1Departments of Pharmacology and Neuroscience, The University of North Texas Health Science Center, Fort Worth, TX 76107, USA.
Experimental biology and medicine (Maywood, N.J.)
|December 7, 2023
概括
老年人经历低血压诱导的大脑低输液缓慢恢复,由于大脑血管自调和心血管反应减弱. 系统性血管收缩是关键的,但其速度随着年龄的增长而下降.
科学领域:
- 生理学 生理学 生理学
- 老年学是一门学科.
- 神经学 神经学
背景情况:
- 姿势低血压可能会导致大脑的低 perfusion,导致不稳定,加剧了老龄化.
- 老年人可能由于脑血管自身调节效率较低和系统性心血管对低血压的反应,导致大脑输液维护受损.
研究的目的:
- 为了研究大脑输液维护在老年人中减弱的假设.
- 为了比较年轻人和老年人的脑血管和全身对低血压的反应.
主要方法:
- 在健康的老年人和年轻成年人中,使用大腿缩引发了全身低血压.
- 记录了心率 (HR),平均动脉压 (MAP) 和中脑动脉血流速度 (VMCA).
- 大脑血管电导率 (CVC) 被计算为VMCA/MAP. 分析了MAP,VMCA,HR和CVC的恢复时间和反应率.
主要成果:
- 低血压和大脑低 perfusion 在两组中都是相似的,但在老年人中恢复显著延长.
- 在低血压后,老年人在HR,MAP和CVC中表现出较慢的反应率.
- 在恢复大脑输液时,全身血管收缩 (ΔMAP) 在心率增加 (ΔHR) 上占主导地位,脑血管导电性 (CVC) 反应也起到了作用.
结论:
- 在老年人中,脑海输液的恢复速度较慢,这是由于与年龄相关的心血管反应和心血管反射调节的下降.
- 大脑血管自身调节和全身机制都会促进恢复,血管运动反应占主导地位.
- 系统性血管收缩在低血压后恢复大脑输液方面比心率增加更为重要.
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