在台湾人群中,HNF4A rs1800961多态和胆结石之间的关联
Ying-Cheng Lin1, I-Chieh Chen2, Yen-Ju Chen2,3,4
1Division of Gastroenterology and Hepatology, Department of Internal Medicine, Taichung Veterans General Hospital, Taichung, Taiwan.
Journal of gastroenterology and hepatology
|December 7, 2023
概括
肝细胞核因子4α (HNF4A) rs1800961变体增加了台湾男性的胆结石风险. 这一遗传因素对于评估年轻或肥胖男性胆结石风险尤为重要.
科学领域:
- 遗传学 遗传学 是一个
- 胃肠病学 胃肠病学
- 流行病学 流行病学
背景情况:
- 全基因组关联研究发现了一种与胆结石相关的新型遗传变异,即肝细胞核因子4α (HNF4A) rs1800961多态.
- 这种变异的遗传效应需要在亚洲人群中进行验证.
研究的目的:
- 调查台湾人群中HNF4A rs1800961变种与胆结石病之间的关联.
- 为了验证在亚洲群体中胆结石相关的遗传效应.
主要方法:
- 来自台湾生物库的20405名参与者 (30-70岁) 的分析.
- 数据收集包括问卷,体检,生物化学测试和基因型.
- 使用多种后勤回归模型分析了HNF4A rs1800961变体和代谢风险与胆结石疾病的关联.
主要成果:
- HNF4A rs1800961的小T等位基因与台湾男性胆结石风险增加显著相关 (调整后OR=1.90,95%CI=1.31至2.75).
- 在调整年龄,BMI,糖尿病,高脂血症,高血压和吸烟后,这种关联仍然显著.
- 石化效应在年轻 (调整的OR=2.45) 和肥胖 (调整的OR=3.55) 的男性参与者中最为明显.
结论:
- 在台湾男性中,HNF4A rs1800961变异与胆结石风险有关.
- 查rs1800961多态可能有助于评估胆结石形成的风险,特别是在年轻或肥胖的男性.
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