艾滋病毒暴露前预防治疗模式在国家卫生计划人口中的治疗模式
Jeremiah Rastegar1, Amy Hu2, Linda Chung2
1Humana Healthcare Research, Inc., Louisville, KY.
Journal of managed care & specialty pharmacy
|December 7, 2023
概括
这项关于艾滋病毒暴露前预防 (PrEP) 的研究发现,虽然最初的坚持率很高,但长期的坚持需要改进. 临床计划可以提高艾滋病毒暴露风险的个人PrEP的有效性.
科学领域:
- 公共卫生 公共卫生
- 传染病流行病学 传染病流行病学
- 药物治疗 药物治疗
背景情况:
- 药物不服药显著降低了预防艾滋病毒的暴露前预防 (PrEP) 的有效性.
- 120万美国人面临艾滋病毒暴露的风险,因此坚持PrEP至关重要.
研究的目的:
- 分析HIV PrEP治疗模式和受益者与医疗保险优势处方药 (MAPD) 计划和商业保险的遵守情况.
- 确定改善长期PrEP坚持的机会.
主要方法:
- 在2012年至2020年期间,对16-89岁的患者进行了 PrEP 发行记录的回顾性队列研究.
- 以覆盖日数比例 (PDC) 衡量在0.60和0.80.0的门时的坚持.
- 分析包括治疗插曲的长度,总治疗时间和处方填充.
主要成果:
- 队列 (N=707) 主要是男性 (90.0%) 和居住在南方 (78.9%),平均年龄为46.2岁.
- 在12个月后,58.7%的人达到PDC≥0.80,74.3%的人达到PDC≥0.60.
- 平均治疗持续时间为297天,平均有16.4次处方填充.
结论:
- 虽然PrEP最初的坚持是相当大的,但显然需要加强长期的坚持.
- 临床计划应侧重于改善风险人群中PrEP持续使用的策略.
- 优化PrEP的坚持是最大限度地提高其在艾滋病毒预防方面的公共健康益处的必要条件.
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