慢性偏素暴露的一些相关缓解剂:治疗治疗
Mohammad Nazari1, Reza Heidari2,3, Zahra Hami1
1Toxicology Research Center, AJA University of Medical Sciences, Tehran, Iran.
Drug and chemical toxicology
|December 7, 2023
概括
食物中的亚拉托克辛会给健康带来诸如癌症之类的风险. 本综述分析了包括补充剂和益生菌在内的18种策略,以减轻这些毒性影响并保护健康.
科学领域:
- 毒理学 毒理学 毒理学
- 食品安全 食品安全
- 公共卫生 公共卫生
背景情况:
- 非洲毒素是来自Aspergillus物种的有毒代谢物,存在于玉米和花生等主食中.
- 长期暴露与肝癌,生长障碍和免疫功能障碍有关.
- 这些真菌毒素对全球健康构成重大关注.
研究的目的:
- 为全面审查18个策略,以减轻青毒素的有害影响.
- 分析这些干预措施的有效性,安全性和作用机制.
- 为了确定人类和动物中与阿弗拉托克辛相关的疾病的潜在治疗方法.
主要方法:
- 对药物,营养药物,补充剂和益生菌干预措施的现有文献的审查.
- 分析包括直接结合,解毒和细胞保护在内的机制.
- 评估影响战略有效性的因素,如剂量和持续时间.
主要成果:
- 几种药物,如蒙莫里隆尼特粘土和Lactobacillus rhamnosus GG,在降低阿弗拉托克辛生物利用性方面表现有前途.
- 食补充剂 (叶绿素,,N-乙半氨酸) 可以抵消氧化应激并支持肝功能.
- 干预措施的目标是直接结合,解毒以及细胞抗氧化/肝细胞保护.
结论:
- 存在多种策略来缓解阿弗拉托克辛毒性,有效性各不相同.
- 进一步的研究对于优化干预和开发有针对性的疗法至关重要.
- 解决阿弗拉托克辛暴露需要采取多方面的方法,考虑到个体的敏感性.
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