ReConPlot:一个用于可视化和解释基因组重组的R包
Jose Espejo Valle-Inclán1, Isidro Cortés-Ciriano1
1European Molecular Biology Laboratory, European Bioinformatics Institute, Wellcome Genome Campus, Hinxton, Cambridge CB10 1SD, United Kingdom.
Bioinformatics (Oxford, England)
|December 7, 2023
概括
ReConPlot 是一个新的 R 包,用于在人类瘤中可视化复杂的基因组重组 (CGR). 它有助于检测和解释结构变异和副本数异常,改善癌症研究.
科学领域:
- 基因组学就是基因组学.
- 生物信息学是一种生物信息学.
- 癌症研究 癌症研究
背景情况:
- 复杂的基因组重组 (CGRs) 在人类瘤中很常见.
- 想象体质拷贝数异常 (SCNA) 和结构变异 (SV) 对于CGR解释至关重要.
- 现有的工具缺乏用于全面CGR可视化的特定功能.
研究的目的:
- 介绍ReConPlot,一个R包用于SCNA和SV的联合可视化.
- 促进对CGR模式的探索,解释和报告.
- 提供一个用户友好的工具来生成出版物质量的数据.
主要方法:
- 开发了ReConPlot作为一个使用ggplot2框架的R包.
- 实现了可视化跨染色体SCNA和SV数据的功能.
- 确保易于定制,以生成高质量的图形.
主要成果:
- ReConPlot可以实现SCNA和SV的集成可视化.
- 该包简化了用于CGR分析的准备发布数据的生成.
- 有助于更深入地了解癌症中复杂的基因组变化.
结论:
- ReConPlot解决了对专门的CGR可视化工具的需求.
- 该包改进了对复杂结构变化的解释和报告.
- ReConPlot 提供了全面的文档和教程.
相关概念视频
Interpreting R Charts
67
R chart, or range chart, is a fundamental tool in statistical process control used to monitor the variability within a process. It complements the X-bar (x̄) chart by focusing on the range of the data, rather than individual values, providing a clear picture of the process dispersion over time.
An R chart plots the range of subsets of measurements collected from a process. Each point on the chart represents the range—defined as the difference between the maximum and minimum...
An R chart plots the range of subsets of measurements collected from a process. Each point on the chart represents the range—defined as the difference between the maximum and minimum...
67
Homologous Recombination
4.6K
4.6K
Overview of Transposition and Recombination
15.5K
Transposons make up a significant part of genomes of various organisms. Therefore, it is believed that transposition played a major evolutionary role in speciation by changing genome sizes and modifying gene expression patterns. For example, in bacteria, transposition can lead to conferring antibiotic resistance. Movement of transposable elements within the genetic pool of pathogenic bacteria can aid in transfer of antibiotic-resistant genetic elements. In eukaryotes, transposons can carry out...
15.5K
Conservative Site-specific Recombination and Phase Variation
6.0K
Because the DNA segments are cut and reorganized in a direction-specific manner, site-specific recombination has emerged as an efficient genetic engineering technique. Flippase and Cyclization recombinases or Flp and Cre, respectively, are two members of the tyrosine recombinase family derived from bacteriophages, that are used to mediate site-specific DNA insertions, deletions, and targeted expression of proteins in mammalian cell lines.
The recognition sites for Cre recombinase called LoxP...
The recognition sites for Cre recombinase called LoxP...
6.0K
Comparing Copy Number Variations and SNPs
17.7K
Sequencing of the human genome has opened up several best-kept secrets of the genome. Scientists have identified thousands of genome variations that exist within a population. These variations can be a single nucleotide or a larger chromosomal variation.
Copy number variations or CNVs are the structural variations that cover more than 1kb of DNA sequence. The single nucleotide polymorphism (SNP), on the other hand, is a single nucleotide change or a point mutation that is found in more than 1%...
Copy number variations or CNVs are the structural variations that cover more than 1kb of DNA sequence. The single nucleotide polymorphism (SNP), on the other hand, is a single nucleotide change or a point mutation that is found in more than 1%...
17.7K
The R Chart
82
In statistical process control, control charts, particularly R charts, are instrumental in monitoring process variations and identifying non-random patterns that run charts might miss. R charts track the variability within process subgroups, which is crucial when standard deviation use is impractical or unknown process variations exist.
R charts are pivotal for pinpointing shifts in process variability. Stability is indicated when all data points remain within the defined upper and lower...
R charts are pivotal for pinpointing shifts in process variability. Stability is indicated when all data points remain within the defined upper and lower...
82


