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CASZ1提高PI3K-AKT-mTOR信号的调节,并促进T细胞急性淋巴细胞白血病

Bruno A Cardoso1, Mafalda Duque1, Ana Gírio1

  • 1Instituto de Medicina Molecular João Lobo Antunes, Faculdade de Medicina, Universidade de Lisboa, Lisbon.

Haematologica
|December 7, 2023
PubMed
概括

转录因子CASZ1b促进T细胞急性淋巴细胞白血病 (T-ALL) 的发展和化学抵抗. 它的表达,由TAL1调节,与T-ALL患者的PI3K-AKT-mTOR通路激活相关.

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