缩小毛孔综合征在儿童中也是一个现实吗?
Mathilde Roussel1, Justine Bacchetta1,2,3, Anne Laure Sellier-Leclerc1
1Service de Néphrologie Rhumatologie et Dermatologie Pédiatrique, Centre de Référence des Maladies Rénales Rares, filière maladies rares ORKID and ERKNet, Hospices Civils de Lyon, Bron, France.
Journal of internal medicine
|December 7, 2023
概括
缩小毛孔综合征 (SPS) 在儿童中的患病率因配方而异,但受影响儿童的CRP和酸盐水平较高表明潜在的长期心血管风险. 在更广泛的儿科小组中需要进一步的研究.
科学领域:
- 儿科脏病学 儿科脏病学
- 评估心血管风险评估
- 全球球膜过率估计估计
背景情况:
- 缩小毛孔综合征 (SPS) 的特点是基于酸的低比率与基于肌素的估计质过率 (eGFRcys/eGFRcreat).
- 虽然在儿童中观察到SPS,但尚未确定与增加发病率或死亡率的确切联系.
- 在成人群体中,SPS与心血管风险增加有关.
研究的目的:
- 用各种膜过率 (GFR) 估计方程来确定儿科队列中SPS的患病率.
- 调查SPS和儿童心血管风险因素之间的潜在关联.
- 用不同的诊断标准比较被诊断为SPS的儿科患者的特征.
主要方法:
- 这项研究包括307名患有风险因素的儿科患者.
- 使用基于肌素的eGFR方程 (CKiDU25,全年光谱 (FAS),欧洲功能联盟 (EKFC)) 和基于cystatin C的eGFR的组合来评估SPS患病率.
- 根据SPS定义,使用FAS和/或EKFC方程对比患者的特征.
主要成果:
- 根据所选择的GFR估计公式和值,SPS的患病率有显著差异.
- 使用FAS和/或EKFC方程诊断出SPS的儿童表现出较高的C反应蛋白 (CRP) 和酸盐水平.
- 在患有SPS的儿童身上也注意到体型较小,这可能表明长期的心血管风险.
结论:
- 儿科患者中SPS的患病率高度依赖于所采用的诊断标准和公式.
- 儿科SPS患者炎症标志物 (CRP) 和酸盐水平升高表明与未来心血管并发症的潜在联系.
- 需要对更大的一般儿科患者群体进行进一步的研究,以证实这些发现,并阐明SPS的长期影响.
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