在急性髓性白血病中,对cuproptosis相关的LncRNAs预测值和相关的CeRNA网络进行了全面的分析
Chun Cao1, Teng Wang1, Yun Luo1
1Department of Hematology, The Second Affiliated Hospital of Chongqing Medical University, Chongqing, China.
Heliyon
|December 7, 2023
概括
这项研究确定了与cuproptosis相关的三个长非编码RNA,可以预测急性髓性白血病 (AML) 的预后. 这一发现为AML提供了潜在的新生物标志物,改善了患者的治疗结果.
科学领域:
- 在瘤学瘤学.
- 分子生物学分子生物学
- 遗传学 是一个遗传学.
背景情况:
- 由于急性髓性白血病 (AML) 的高复发率和死亡率,它带来了重大挑战.
- 细胞亡是一种受调节的细胞死亡途径,涉及到各种固体瘤,但其在AML病变发生中的作用仍未得到充分研究.
- 长非编码RNAs (lncRNAs) 在调节AML中cuproptosis基因中的参与是一个新的研究领域.
研究的目的:
- 确定与cuproptosis相关的lncRNAs并开发急性髓性白血病 (AML) 的预后特征.
- 研究这些lncRNAs在AML病变发生中的潜在作用及其与临床特征的相关性.
- 探索潜在的分子机制,包括竞争的内源RNA (ceRNA) 网络.
主要方法:
- 在AML与正常样本 (TCGA,GTEx) 中对cuproptosis基因的差异表达分析.
- 使用相关性和Cox回归分析识别预后性cuproptosis相关的lncRNAs.
- 使用 LASSO 考克斯回归和验证使用卡普兰-梅尔,ROC 曲线和名组图的多基因风险特征的开发.
主要成果:
- 建立了三种lncRNA风险特征,具有AML的优异预后潜力.
- 风险模型在预测患者存活率方面表现出很高的准确性,并得到了nomogram的增强.
- 功能丰富分析揭示了与炎症和免疫通路的关联; TRAF3IP2-AS1被确定为潜在的ceRNA调节器.
结论:
- 开发的风险标志作为预测AML预后的可靠生物标志物.
- 这些发现提供了关于cuproptosis和相关 lncRNAs在AML中的作用的新见解,可能指导未来的治疗策略.
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