在COVID-19患者中使用casirivimab-imdevimab组合的有效性和安全性:系统性审查和元分析随机对照试验
Imam Adi Wicaksono1, Cecep Suhandi2, Khaled M Elamin3
1Department of Pharmacology and Clinical Pharmacy, Universitas Padjadjaran, Sumedang 45363, West Java, Indonesia.
Heliyon
|December 7, 2023
概括
在一个系统性审查中,抗SARS-CoV-2疗法Casirivimab-imdevimab显著降低了COVID-19死亡率和症状进展. 这种治疗还改善了病毒清除率和出院率,具有良好的安全性.
科学领域:
- 传染性疾病 传染性疾病
- 病毒学 病毒学
- 临床医学 临床医学
背景情况:
- 对于2019年冠状病毒病 (COVID-19) 的casirivimab-imdevimab的治疗益处和风险仍然不完全理解.
- 进行了系统性审查和元分析,以评估casirivimab-imdevimab在COVID-19患者中的疗效和安全性.
研究的目的:
- 为了确定casirivimab-imdevimab在COVID-19患者中的治疗有效性.
- 评估与casirivimab-imdevimab治疗相关的潜在副作用.
- 将casirivimab-imdevimab结局与安慰剂或标准护理进行比较.
主要方法:
- 系统的文献搜索进行到2023年2月28日.
- 包括8项涉及19,819名患者的研究;使用Cochrane工具评估偏差风险.
- 主要结局:28天死亡率,症状进展,病毒载量,出院和不良事件.
主要成果:
- 卡西里维马布-米德维马布显著降低了28天死亡率 (OR=0.62) 和临床症状进展 (OR=0.86).
- 治疗表明病毒载荷清除率和医院出院率有所改善.
- 与对照组相比,与casirivimab-imdevimab一起观察到不良事件的轻微减少.
结论:
- 建议Casirivimab-imdevimab作为一种有价值和有效的抗SARS-CoV-2疗法.
- 这些发现支持casirivimab-imdevimab在COVID-19治疗中的安全性.
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