在没有大肠炎的患者中,早期诊断出单微生物Clostridioides difficile细菌病
Jennifer Tat1, Sigmund Krajden1,2,3, Samir N Patel1,4
1Department of Laboratory Medicine and Pathobiology, University of Toronto Temerty Faculty of Medicine, Toronto, Ontario, Canada.
概括
由于Clostridioides difficile感染引起的细菌病很少见. 这一案例突出了在没有典型症状的患者中使用血培粒和MALDI-TOF的早期诊断,使得迅速治疗成为可能.
科学领域:
- 医学微生物学 医学微生物学
- 传染性疾病 传染性疾病
- 临床诊断 临床诊断 临床诊断
背景情况:
- 细菌病是Clostridioides difficile感染的一种不常见的并发症.
- 困难菌感染 (CDI) 通常伴有腹和结肠炎.
研究的目的:
- 为了报告一个罕见的Clostridioides difficile bacteremia病例.
- 在早期诊断中强调矩阵辅助激光脱离/离子化飞行时间 (MALDI-TOF) 的实用性.
主要方法:
- 血培养对格拉姆阳性细菌呈阳性.
- 使用血液培养颗粒和MALDI-TOF进行推定鉴定.
- 通过常规培养和参考实验室识别进行确认.
- 对万科米辛治疗的临床反应.
主要成果:
- 在患有小肠阻塞的患者的血液培养物中确定了困难的闭塞性菌.
- 患者缺乏典型的CDI症状 (腹,大肠炎).
- 早期诊断促进了适当的抗微生物治疗和患者的康复.
结论:
- MALDI-TOF与血液培养颗粒化相结合,可以加快对C. difficile细菌病的诊断.
- 及时诊断对于有效的治疗和感染控制至关重要.
- 这一案例强调了在非经典呈现中考虑C. difficile的重要性.
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