晚期加多增强与扩张性心肌病的结果之间的关联:元分析
Xin-Yi Feng1, Wen-Feng He2, Tian-Yue Zhang1
1Department of Radiology, The Affiliated Hospital of North Sichuan Medical College, Nanchong 637000, Sichuan Province, China.
World journal of radiology
|December 7, 2023
概括
晚期加多增强 (LGE) 在心血管磁共振 (CMR) 上显著预测扩张性心肌病 (DCM) 的不良结果. 像范围和模式这样的LGE特征为完善患者风险分层提供了关键细节.
科学领域:
- 心脏病学 心脏病学
- 医疗成像医学成像
- 心血管疾病 心血管疾病
背景情况:
- 通过心血管磁共振 (CMR) 的晚期加多增强 (LGE) 已经在心血管疾病中建立了预后价值.
- 新兴的LGE指标需要进一步调查,以准确地分层扩张性心肌病 (DCM) 的风险.
研究的目的:
- 评估LGE特征 (阳性,程度,位置,模式) 与DCM患者的不良结果之间的关联.
- 探索LGE在改善DCM患者风险分层中的作用.
主要方法:
- 在PubMed,Ovid MEDLINE和Cochrane图书馆进行了系统的文献搜索.
- 对19项研究 (7330名患者) 进行了元分析,以计算LGE和不良事件的聚合危险比率.
- 亚组分析根据LGE的位置和模式检查了LGE的预后影响.
主要成果:
- 存在LGE显著增加了所有原因死亡的风险 (HR:2.14),心律失常事件 (HR:5.12) 和复合终点 (HR:2.38).
- 每增加1%的LGE程度与更高的全因死亡风险相关.
- 在DCM患者中,LGE对心律失常事件的预测更强,其左心室喷射率较高.
结论:
- 通过CMR检测到的LGE是DCM中不良结果的强有力的预测器.
- LGE的程度,位置和模式为DCM患者的风险分层增强提供了有价值的补充信息.
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