传统与基于液体的细胞学:"人与机器"
Saleem Pathuthara1, Swati Dighe1, Maya Uke1
1Department of Cytopathology, Tata Memorial Hospital, Tata Memorial Centre, Homi Bhabha National Institute, Mumbai, Maharashtra, India.
Journal of cytology
|December 7, 2023
概括
基于液体的细胞学 (LBC) 和传统的涂抹 (CS) 显示了类似的诊断充分性. 虽然LBC提供了更干净的背景,但CS在检测炎症和生物体方面表现出色,这对于这两种方法都至关重要.
科学领域:
- 细胞病理学 细胞病理学
- 诊断细胞学 诊断细胞学
- 妇科和非妇科样本分析分析.
背景情况:
- 基于液体的细胞学 (LBC) 可能会比传统的涂抹 (CS) 提高样本的充分性和质量.
- LBC提供了更清洁的背景和单层细胞分布.
- 传统的涂抹 (CS) 是一种长期以来的细胞学技术.
研究的目的:
- 在常规细胞学调查中,比较LBC与CS的诊断质量和产量.
- 评估特定参数,包括细胞性,背景,炎症和恶性瘤检测.
- 评估两种方法之间的准备和选时间差异.
主要方法:
- 从2019-2020年对306个样本 (妇科,非妇科,FNAC) 的回顾性研究.
- 采集双对样本:每个患者的两个样本通过CS和LBC (ThinPrep®) 进行处理.
- 充分性,质量,代表性,炎症,出血,亡,保存,反应性变化,有机体,异型/异形/恶性病变以及处理/查时间的比较.
主要成果:
- 在充分性,代表性,反应性变化,保存或恶性瘤检测方面没有统计学上显著的差异.
- 传统的涂抹 (CS) 显示出更好的细胞性和炎症和生物体的诊断.
- 基于液体的细胞学 (LBC) 产生了一个明显更清洁的背景 (P = 0.0005).
结论:
- 在充分性和恶性瘤检测方面,CS与LBC相似,通过谨慎的技术有可能得到改善.
- CS在检测有机体和炎症方面表现出优越性.
- 在涂抹质量和查时间方面,LBC具有优势,但成本较高,处理时间较长,因此适用于特定的实验室环境.
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