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血清神经素2与认知功能障碍和脑电图慢波/快波频率比在中有关

Xiao-Fen Huang¹, Ming-Xia Xu¹, Yue-Fan Chen¹

¹Department of Neurosurgery, The First Affiliated Hospital of Fujian Medical University, Fuzhou 350005, Fujian Province, China.

World journal of psychiatry

|December 7, 2023

概括

血清神经素2 (NPTX2) 水平与患者的认知功能相关. 下NPTX2可能表明认知障碍,表明其作为诊断生物标志物的潜力.

科学领域:

神经科学是一个神经科学.
生物标志物生物标志物
的研究研究.

背景情况:

由于神经系统受损,在患者中常见的是认知功能障碍.
目前,对于这种并发症,没有有效的诊断生物标志物.
神经元素2 (NPTX2) 对于神经传递和突触可塑性至关重要.

研究的目的:

研究患者血清NPTX2水平与认知功能障碍之间的关系.
探索NPTX2作为用于诊断症认知障碍的生物标志物的潜力.

主要方法:

该研究包括74名具有正常认知的患者,37名认知功能障碍患者 (ECD组) 和30名健康对照.
认知功能被评估使用迷你精神状态检查 (MMSE) 尺度.
用ELISA测量血清NPTX2水平,并计算EEG慢/快波比率.

主要成果:

与对照组和正常认知组相比,ECD组的血清NPTX2水平较低 (193.80 ± 42.72 pg/mL).
在患有认知功能障碍的患者中,NPTX2与MMSE得分 (r = 0.367,P = 0.0253) 有正相关性.
在部区域,NPTX2水平与持续时间和EEG慢/快波比率有负相关性.

结论:

血清NPTX2与患者的认知功能障碍有关.
NPTX2水平与EEG变化和疾病持续时间相关.
血清NPTX2显示为潜在的生物标志物,用于诊断中的认知障碍.

关键词:

生物标志物生物标志物认知功能障碍认知功能障碍电脑图中慢波/快波频率比率是什么是一种病.血清神经元素2 血清神经元素2

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