在患有心房动的老年患者中,出现左心房附属体血栓的风险
Monika Gawałko1, Monika Budnik1, Beata Uziębło-Życzkowska2
11 Department of Cardiology, Medical University of Warsaw, Warsaw, Poland.
Archives of medical science : AMS
|December 7, 2023
概括
老年心房患者有较高的风险左心房附属体血栓尽管口服抗凝药. 关键预测因素包括年龄较大,非发热性AF和心力衰竭.
科学领域:
- 心脏病学 心脏病学
- 老年病的医生 老年病的医生
- 血管医学 血管医学
背景情况:
- 心房动 (AF) 是一种常见的心律失常症,与血栓栓塞的风险增加有关,特别是左心房附属体 (LAA) 血栓.
- 年龄是心血管疾病的重要风险因素,包括AF及其并发症.
研究的目的:
- 为了比较LAA血栓及其预测因子在老年人 (≥65岁) 和年轻人 (<65岁) 患有AF的患病率.
- 为了确定AF患者LAA血栓形成的年龄特异性风险因素.
主要方法:
- 一项对1970年接受过食管回声心脏成像 (TEE) 检查AF心脏转换或切除的患者的回顾性研究.
- 患者被分为两组:≥65岁和<65岁.
- 记录了口服抗凝剂 (OAC) 的使用和类型 (维生素K对抗剂 - VKA与非VKA-OAC - NOAC). 多变量逻辑回归被用来确定LAA血栓的预测因子.
主要成果:
- 与年轻患者 (4.0%) 相比,老年患者 (7.7%) 的LAA血栓更为普遍 (p < 0.001).
- 老年患者更有可能接受OAC (97.2% vs 91.8%,p < 0.001) 并偏爱NOAC而不是VKA.
- 在这两组中,LAA血栓的独立预测因素包括年龄较大,非发热性AF和心力衰竭. 特定于年龄的预测因素是老年患者的较低膜过率和血小板计数,年轻患者的VKA使用.
结论:
- 尽管OAC使用率相似,但老年AF患者的LAA血栓患病率更高.
- 年龄,非发热性肌肉衰竭和心力衰竭是LAA血栓的普遍预测因素.
- 年龄特定的因素,如老年人的功能和血小板计数,以及年轻人的VKA使用,也会导致LAA血栓风险.
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