抗胰岛素H1对食道状细胞癌患者的生存结果的使用,这些患者同时接受化疗或放射治疗
Chia-Lun Chang1,2, Kuan-Chou Lin3,4, Wan-Ming Chen5,6
1Department of Hemato-Oncology, Wan Fang Hospital, Taipei Medical University Taipei, Taiwan.
American journal of cancer research
|December 7, 2023
概括
在食道状细胞癌 (ESCC) 的同时化学放射治疗 (CCRT) 期间使用抗组胺H1 (AH1) 药物显著改善了患者的生存率. 这项研究发现,AH1的使用与接受CCRT的ESCC患者的更好的整体和癌症特异性生存结果有关.
科学领域:
- 在瘤学瘤学.
- 药理学 药理学是指药理学的学科.
- 流行病学 流行病学
背景情况:
- 食道状细胞癌 (ESCC) 在台湾是一个重大的死亡挑战,与标准并发化学放射治疗 (CCRT) 相比,生存率的改善有限.
- 抗胰岛素H1 (AH1) 具有潜在的抗癌特性,包括免疫调节和激酶通路激活,但它们在ESCC治疗中的作用尚不清楚.
研究的目的:
- 为了研究抗胰岛素H1 (AH1) 在并发化疗 (CCRT) 期间使用与食道状细胞癌 (ESCC) 患者的生存结果之间的关联.
主要方法:
- 一项倾向分数匹配的队列研究利用了来自台湾癌症登记和国家健康保险研究数据库的数据.
- 这项研究包括981名接受CCRT的ESCC患者,比较了309名非使用者和672名AH1用户之间的结果.
- 多变量Cox比例危险回归模型分析了整体和ESCC特定的生存率,评估了AH1使用的影响.
主要成果:
- 在CCRT期间使用AH1显着与改善的整体存活率 (调整HR,0.52;P<0.0001) 和ESCC特异性存活率 (调整HR,0.47;P<0.0001) 相关.
- 观察到剂量-反应关系,较高的累积AH1剂量与死亡率降低相关.
- 对于最低的死亡率,确定了0.84定义的每日剂量AH1的最佳每日强度剂量.
结论:
- 在并发化疗放射治疗 (CCRT) 期间使用抗组胺H1 (AH1) 与提高整体和食道状细胞癌 (ESCC) 特定存活率有关.
- 研究结果表明,AH1可能是接受CCRT的ESCC患者有益的辅助疗法,需要进一步调查.
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