在确定酒精使用障碍的样本中,对自杀思想和行为的多基因贡献
Sarah M C Colbert1, Niamh Mullins1,2,3, Grace Chan4
1Department of Psychiatry, Washington University School of Medicine, St. Louis, MO, USA.
Complex psychiatry
|December 7, 2023
概括
自杀行为的遗传风险得分,除了抑郁症之外,显著预测了自杀念头和企图. 这些多基因风险评分 (PRS) 突出了各种自杀思想和行为的独特遗传基础.
科学领域:
- 精神病学是一个精神病学.
- 遗传学 是一个遗传学.
- 公共卫生 公共卫生
背景情况:
- 自杀的想法和行为 (STBs) 是复杂的现象,具有重大的公共卫生影响.
- 了解性病的遗传结构对于开发有针对性的干预措施至关重要.
- 以前的研究表明,不同类型的性传播疾病的遗传病因部分不同.
研究的目的:
- 通过使用多基因风险评分 (PRSs) 调查各种性病之间的遗传重叠和特异性.
- 为了确定抑郁症的遗传风险是否解释了性传播疾病的遗传变异.
- 为了确定不同STB相关特征的特定遗传贡献,以一系列的自杀结果.
主要方法:
- 利用PRS-CS从全基因组关联研究 (GWAS) 中生成PRS,用于非自杀自伤,自伤想法,自杀企图,自杀死亡和抑郁症.
- 应用混合效应模型来评估这些PRS与大量STB在一个大队列中的相关性 (N = 7,526).
- 在回归模型中单独和同时检查PRS的预测能力.
主要成果:
- 所有生成的PRS都与自杀念头和自杀企图有显著的关联.
- 抑郁症的PRS没有完全解释STB的遗传变异,表明STB特异性PRS的独特贡献.
- 抑郁症,非自杀自伤和自杀企图的PRS总体解释了自杀企图变异的6.2%.
- 在各种PRS和特定的性病之间发现了显著的关联,包括活跃的自杀念头,持久的自杀念头和死亡欲望.
结论:
- 自杀想法和行为的遗传风险并不能完全由抑郁症的遗传风险来解释.
- 从自杀行为中获得的PRS为其遗传病因提供了独特的见解.
- 这些发现强调了考虑自杀现象不同表现的独特遗传因素的重要性.
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