输入/删除多态酶和COVID-19的风险之间的关系:一个元分析
Hu Luoyi1, Pan Yan1, Fan Qihong1
1Department of Pediatrics, The First Affiliated Hospital of Yangtze University, Jingzhou, Hubei Province, China.
Journal of the renin-angiotensin-aldosterone system : JRAAS
|December 7, 2023
概括
血管激素转化酶 (ACE) 删除/插入 (D/I) 多态性与COVID-19风险无关. 然而,ACE D等位基因与COVID-19严重程度的增加有关,突出显示了遗传因素的作用.
科学领域:
- 遗传学 是一个遗传学.
- 传染性疾病 传染性疾病
- 心血管研究研究心血管研究
背景情况:
- 血管激素转化酶 (ACE) 删除和插入 (D/I) 多态性已被研究其与COVID-19易感性和严重性的潜在关联.
- 现有研究提出了关于ACE I/D多态和COVID-19风险之间的相关性的相互矛盾的证据.
研究的目的:
- 进行元分析,准确评估ACE I/D多态性和患COVID-19的风险之间的关系.
- 为了调查ACE I/D多态与COVID-19严重性的关联.
主要方法:
- 来自PubMed数据库的研究的系统文献综述.
- 8项研究的元分析,包括1362例COVID-19病例和4312例对照.
- 使用几率比率 (OR) 和95%置信区间 (CI) 的统计分析,使用Stata版本15.0.0.
主要成果:
- ACE I / D 多态性没有显示与COVID-19的整体风险有显著的关联.
- 亚组分析显示,ACE D等位基因与COVID-19严重性风险增加有关.
- 具体的模型 (主要的,衰退的,D与D对比. I,DD与II,DI与II) 表示D等位基因具有更高的严重性风险.
结论:
- 显然,ACE D等位基因与COVID-19严重性风险的增加有关.
- 在开发未来的疫苗和COVID-19治疗策略时,应考虑ACE多态性等遗传因素.
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