印度人口中维生素D和膝关节骨关节炎之间的关联:系统性审查和元分析
R Annamalai1, A Sujhithra2, D Danis Vijay3
1Department of Orthopedics, Karpaga Vinayaga Institute of Medical Sciences and Research Centre, P.O, GST Road, Chinna Kolambakkam, Palayanoor, Maduranthakam, 603 308, Tamilnadu, India.
Journal of clinical orthopaedics and trauma
|December 7, 2023
概括
维生素D缺乏 (VDD) 与印度和亚洲人群的膝关节骨关节炎 (KOA) 有关. 早期查和管理VDD可能有助于减缓KOA的进展.
科学领域:
- 整形外科 整形外科 整形外科
- 内分泌学 在内分泌学.
- 营养科学 营养科学
背景情况:
- 维生素D缺乏 (VDD) 越来越多地与膝关节骨关节炎 (KOA) 的发展和进展有关.
- 在印度KOA人口中报告了低维生素D和骨质疏松症的高患病率.
- 缺乏对印度VDD和KOA现有研究的批判性评估.
研究的目的:
- 系统地审查和批判性地评估有关膝关节骨关节炎和维生素D水平之间的联系的研究.
- 将印度人口的发现与其他亚洲人口进行比较.
- 确定维生素D状态与发展KOA的风险之间的相关性.
主要方法:
- 在PubMed,谷歌学者和科学网上进行了系统的文献搜索,直到2023年3月.
- 审查了在印度和亚洲人群中考察KOA和维生素D水平之间的关联的符合条件的研究.
- 进行了元分析,以计算维生素D水平的平均差异和维生素D状态的几率比,并使用Cochrane工具评估偏差风险.
主要成果:
- 该审查包括15项涉及1503例KOA病例和1609例对照的研究.
- 在印度KOA患者 (MD -8.68 ng/mL) 和其他亚洲人群 (MD -18.36 ng/mL) 中观察到显著降低的维生素D水平.
- 发现维生素D缺乏与膝关节骨关节炎风险增加正相关.
结论:
- 早期诊断和维生素D缺乏的管理可能会延迟膝关节骨关节炎的退行过程.
- 这项研究强调了查维生素D缺乏的重要性,即使在阳光充足的地区.
- 解决维生素D水平可能是治疗膝关节关节炎的关键组成部分.
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