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Updated: Jul 9, 2025

High-Throughput Cellular Profiling of Targeted Protein Degradation Compounds Using HiBiT CRISPR Cell Lines
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High-Throughput Cellular Profiling of Targeted Protein Degradation Compounds Using HiBiT CRISPR Cell Lines

Published on: November 9, 2020

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胰岛素类生长因子2-标记的阿普塔默基默 (ITACs) 模块化组件,用于针对性和有效地降解两个膜蛋白

Yuan Tian1, Yanyan Miao1, Pei Guo2

  • 1Institute of Molecular Medicine and Shanghai Key Laboratory for Nucleic Acid Chemistry and Nanomedicine, State Key Laboratory of Systems Medicine for Cancer, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, 200127, China.

Angewandte Chemie (International ed. in English)
|December 7, 2023
PubMed
概括

我们开发了与胰岛素类似的生长因子2 (IGF2) 标记的体体仿真体 (ITACs),以有效降解膜蛋白质. 这个平台可以同时降解多种蛋白质,为相关疾病提供新的治疗途径.

关键词:
亚博体育官网 亚博体育官网 亚博体育官网 亚博体育官网 亚博体育官网双蛋白降解过程中的二重蛋白降解IGF2 IGF2 的意思是什么膜蛋白是一种膜蛋白.有针对性的蛋白质降解.

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