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手术后的外分胰腺功能不充分症
Maria B Garay1, Ángela L Carbajal-Maldonado1, Rosario Rodriguez-Ortiz-DE-Rozas1
1Department of Gastroenterology, Instituto de Investigación Sanitaria y Biomédica de Alicante (ISABIAL), General University Hospital of Alicante, Alicante, Spain.
Minerva surgery
|December 7, 2023
概括
手术性胰腺外分缺陷 (PSP) 是胃肠道手术后被诊断不足的疾病. 早期诊断和胰腺酶替代疗法 (PERT) 对于管理吸收不良和改善生活质量至关重要.
科学领域:
- 胃肠病学 胃肠病学
- 手术瘤学手术瘤学
- 消化系统健康 消化系统健康
背景情况:
- 手术性胰腺外分缺陷 (PSP) 是一种经过上部消化道,胆道或胰腺手术而导致的未被确诊的胃肠道 (GI) 疾病.
- 它导致胰腺酶的生产不足,导致吸收不良,营养不良和生活质量下降.
- 危险因素包括年龄,肥胖,吸烟,糖尿病病史,恶性瘤,,黄,减肥和手术内胰腺质地.
研究的目的:
- 审查手术性胰腺外分缺陷 (PSP) 的诊断和管理.
- 突出各种胰腺和胃肠道手术后PSP的流行情况.
- 强调及时使用胰腺酶替代疗法 (PERT) 治疗的重要性.
主要方法:
- 关于手术性胰腺外分缺陷 (PSP) 研究的文献综述.
- 分析不同手术程序 (PD,DP,CenP) 和慢性胰腺炎 (CP) 干预的PSP流行数据.
- 对便弹性酶-1 (FE-1) 等诊断工具和PERT治疗指南的审查.
主要成果:
- 胰腺二管切除术 (PD) 显示PSP的患病率很高 (19-100%),而远端胰腺切除术 (DP) 和中央胰腺切除术 (CenP) 的患病率较低 (0-82%和3.66-8.7%).
- 像Partington-Rochelle和Frey这样的特定CP程序也报告了高PSP率 (>80%).
- 便弹性酶-1 (FE-1) 是一个经过验证的诊断标记物,PERT有效地管理症状.
结论:
- 胃肠炎是胃肠道和胰腺手术的严重并发症,经常被诊断不足和治疗不足.
- 使用FE-1进行准确的诊断和迅速启动PERT对于患者的治疗结果至关重要.
- 持续监测营养不良和量身定制的PERT剂量是PSP管理的建议.
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