系统性红斑狼的胃肠道表现:来自印度多机构初始 (INSPIRE) 队列的数据
Pankti Mehta1,2, Amita Aggarwal1, Liza Rajasekhar3
1Department of Clinical Immunology and Rheumatology, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow, India.
Rheumatology (Oxford, England)
|December 7, 2023
概括
胃肠道 (GI) 症状影响了近10%的系统性红斑狼 (SLE) 患者,增加了死亡风险. 早期干预和管理疾病活动对于改善这些患者的治疗结果至关重要.
科学领域:
- 类风湿病学 类风湿病学
- 胃肠病学 胃肠病学
- 流行病学 流行病学
背景情况:
- 系统性红斑狼 (SLE) 是一种慢性自身免疫性疾病,具有多样化的临床表现.
- 在SLE中胃肠道 (GI) 的参与可能是复杂的,并影响患者的结果.
- 了解胃肠道表现的患病率和相关情况对于有效管理至关重要.
研究的目的:
- 确定印度SLE患者全国队列中的GI表现的患病率,相关因素和结果.
- 为了比较SLE患者的临床和实验室特征,包括GI参与和没有GI参与.
- 为了确定与SLE患者的死亡率相关的因素,有GI表现.
主要方法:
- 一项观察性队列研究分析了INSPIRE队列的基线数据库.
- 使用BILAG指数识别出患有胃肠道症状的患者.
- 检索了临床和实验室数据,并比较了有和没有胃肠道症状的患者. 确定了与死亡相关的因素.
主要成果:
- 在2503名SLE患者中,有9.7%的患者出现了胃肠道表现,其中最常见的是炎.
- 与对照组 (6.6%) 相比,患有胃肠道表现的患者的死亡率显著更高 (11.9%).
- 低社会经济地位和较高的SLEDAI 2K得分与GI组的死亡率增加有关.
结论:
- 胃肠道表现是SLE患者的一个显著的早期并发症,与系统性疾病活性增加有关.
- 这些表现与较高的死亡率有关,强调需要谨慎监测和管理.
- 诸如低社会经济地位和疾病活动评分等因素预测,患有胃肠道疾病的SLE患者的治疗结果会更差.
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