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在患有牛皮的患者中改变了大脑活动和认知障碍

Xiaoping Yi^1,2,3,4,5,6, Xueying Wang^1,3, Yan Fu^1,3

¹Department of Radiology, Xiangya Hospital, Central South University, Changsha, Hunan, China.

Journal of the European Academy of Dermatology and Venereology : JEADV

|December 7, 2023

概括

患有牛皮的患者表现出大脑活动和连接能力的改变,特别是在默认模式网络 (DMN) - 前额回路内. 这些神经变化与牛皮患者观察到的认知障碍有关.

科学领域:

神经科学是一个神经科学.
精神病学是一个精神病学.
放射学放射学是一门学科.

背景情况:

牛皮与潜在的认知障碍有关.
关于牛皮患者内在大脑活动和认知功能的研究有限.

研究的目的:

为了研究牛皮患者内在大脑活动的变化.
确定大脑活动变化与认知功能之间的关联.

主要方法:

222名牛皮患者和144名健康对照 (HCs) 接受了休息状态功能磁共振成像 (rs-fMRI).
rs-fMRI数据分析了低频波动 (ALFF) 和功能连接 (FC) 的幅度.
神经心理测试评估认知功能;进行相关分析.

主要成果:

牛皮患者在认知测试 (Trail Making Test,数字跨度测试,Stroop Color-Word测试) 中表现较差.
患者在特定的额头和前皮区域呈现下降的ALFF,并在近中心叶片中增强的ALFF.
改变的ALFF与认知评估相关,在DMN前额回路内观察到增加的FC.

结论:

牛皮患者在DMN前额网络内表现出改变的内在大脑活动和连接性.
这些神经变化可能代表了牛皮认知缺陷的潜在机制.
这些发现突出了脑部变化和牛皮的认知功能之间的联系.

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