肠道微生物群与血清费里和认知相关
Marisel Rosell-Díaz1,2,3, Elena Santos-González1,2,3, Anna Motger-Albertí1,2,3
1Department of Diabetes, Endocrinology and Nutrition, Dr. Josep Trueta University Hospital, Girona, Spain.
Gut microbes
|December 7, 2023
概括
血清费里丁 (SF) 与更好的执行功能 (EF) 有关. 肠道细菌及其代谢物,如甲胺,可能解释这种铁-认知联系.
科学领域:
- 微生物组研究的研究.
- 神经科学是一个神经科学.
- 代谢学 代谢学 代谢学
背景情况:
- 铁对于细菌生长和神经递质生产等人类功能至关重要.
- 肠道微生物群影响铁代谢和认知,但相互作用尚不清楚.
- 之前的工作将血清费里丁 (SF) 与执行功能 (EF) 积极联系起来.
研究的目的:
- 研究SF,肠道微生物组和认知功能之间的关联背后的机制.
- 探索微生物代谢物在铁认知轴中的作用.
主要方法:
- 使用猎枪元基因组学分析肠道微生物组.
- 通过HPLC-ESI-MS/MS进行血代谢组分析.
- 在老化影像学队列 (n=1,030) 中,与认知测试 (SVF,TDS,PVF) 的相关性分析.
主要成果:
- 在特定细菌 (蛋白质细菌:Klebsiella,Escherichia) 和SF/EF之间发现了负相关性.
- 在氨酸,氨酸和氨酸代谢中丰富的微生物途径.
- 乙烯基胺,尿酸和19,20-DiHDPA与SF和EF负相关;埃可索胺酸与SF和EF正相关.
结论:
- 肠道微生物组及其代谢物调解SF和认知功能之间的关系.
- 微生物的氨酸代谢和其他途径都涉及到铁认知交叉.
- 这些发现突出了肠道微生物组作为铁对认知的影响的关键参与者.
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