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Updated: Jul 9, 2025

High-Throughput Cellular Profiling of Targeted Protein Degradation Compounds Using HiBiT CRISPR Cell Lines
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针对蛋白质降解的双功能类纳米纤维

Zongtao Lin1, Benjamin A Garcia1, Dongwen Lv2

  • 1Department of Biochemistry and Molecular Biophysics, Washington University in St. Louis, 4523 Clayton Avenue, St. Louis, MO 63110, USA.

Angewandte Chemie (International ed. in English)
|December 7, 2023
PubMed
概括

一种基于纳米纤维的新方法,Nano-PROTAC,通过形成多元复合体来实现向蛋白质降解 (TPD). 这一创新策略为癌症治疗提供了一条新的途径,通过降低以前无法治疗的目标来治疗癌症.

关键词:
癌症 癌症 癌症 癌症纳米纤维的纳米纤维这就是PROTAC.自动组装自动组装有针对性的蛋白质降解.

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