相关实验视频
Updated: Jun 27, 2026

10:45
Histological Analyses of Acute Alcoholic Liver Injury in Zebrafish
Published on: May 25, 2017
14.4K
阿克尔曼西亚菌和与酒精有关的肝脏疾病. 一个系统的审查
Lydie Sparfel1, Sandy Ratodiarivony2, Elisa Boutet-Robinet3
1Univ Rennes, Inserm, EHESP, Irset (Institut de recherche en santé, environnement et travail) - UMR_S 1085, Rennes, F-35000, France.
Molecular nutrition & food research
|December 7, 2023
概括
肠道细菌Akkermansia muciniphila与代谢健康有关. 补充剂有望改善与酒精有关的肝脏疾病,突出其益生菌潜力.
科学领域:
- 微生物学 微生物学
- 胃肠病学 胃肠病学
- 肝病学 肝病学是一种肝病学.
背景情况:
- 阿克尔曼西亚·穆奇尼菲拉 (A. muciniphila) 是一种能降解粘素,影响肠道透性和炎症的グラム阴性细菌.
- 在肥胖,糖尿病,代谢综合征和炎症性消化系统疾病中观察到较低的A. muciniphila水平.
- 乙醇消费减少了A. muciniphila,导致失生症,肠道屏障受损和慢性炎症.
研究的目的:
- 审查A. muciniphila. 的细菌学特征.
- 为了确定调节A. muciniphila在消化道中的丰富度的因素.
- 评估A. muciniphila在与酒精有关的肝脏疾病中的益生菌潜力.
主要方法:
- 在文献综述中采用了PRISMA搜索策略.
- 审查的重点是A. muciniphila的特征,丰富度调节剂和益生菌应用.
- 研究的特定与酒精有关的肝病包括酒精性肝炎,肝硬化,肝细胞癌和手术后状态.
主要成果:
- A. muciniphila 在调节肠道透性和炎症方面发挥作用.
- 确定了影响A. muciniphila丰富性的因素.
- 该综述综合了关于A. muciniphila对各种酒精诱导的肝病理影响的数据.
结论:
- 用A. muciniphila补充剂在改善与乙醇相关的肝病理方面表现出有效性.
- A. muciniphila 是一个有前途的候选人 益生菌用于管理酒精诱导的肝损伤.
相关概念视频
Diseases of the Liver and Gallbladder
Liver and gallbladder diseases are a significant health concern, with prominent conditions including cirrhosis, hepatitis, non-alcoholic fatty liver disease (NAFLD), and gallstones. Jaundice is a common manifestation of liver and biliary disease.
Cirrhosis is characterized by the scarring of hepatic lobules in the liver, which are replaced by fibrous tissue, affecting the liver's normal functioning. NAFLD, on the other hand, is caused by an excessive build-up of fat in the liver, not related to...
Cirrhosis is characterized by the scarring of hepatic lobules in the liver, which are replaced by fibrous tissue, affecting the liver's normal functioning. NAFLD, on the other hand, is caused by an excessive build-up of fat in the liver, not related to...
Microbial Fermentation
Fermentation is a crucial anaerobic metabolic process that enables microbes to derive energy from sugar without relying on oxygen or an electron transport chain. This process is fundamental to various biological and industrial applications and is classified based on the metabolic products generated.Role of Pyruvate in FermentationPyruvate and its derivatives serve as key electron acceptors in fermentative pathways. The oxidation of NADH to regenerate NAD+ is essential for the continuation of...
Microbes in Food Production
Microbial fermentation is central to food biotechnology, enhancing flavor, texture, preservation, and stability. Fermentative microorganisms metabolize carbohydrates into organic acids, alcohols, and other metabolites that inhibit spoilage organisms and improve digestibility while contributing distinctive sensory qualities.In baking, amylases naturally present in flour hydrolyze starch into monosaccharides such as glucose, which Saccharomyces cerevisiae ferments anaerobically. Through...
Microbes in Beverage Production
Alcoholic beverages such as wine, beer, and spirits are the products of microbial fermentation processes that transform simple sugars into ethanol and a wide array of complex flavor compounds. These transformations rely on the metabolic activities of specific yeasts and bacteria, which are selected and controlled to yield the desired beverage characteristics.Wine Fermentation and MaturationWine production begins with the crushing of grapes to release juice and pulp, forming a must that is...
Production of Alcohol
Continuous fermentation is a key strategy in industrial ethanol production, particularly when efficiency, scalability, and high yields are essential. This approach allows for uninterrupted operation and optimized resource utilization. The primary feedstock, corn starch, undergoes enzymatic hydrolysis facilitated by α-amylase and glucoamylase. These enzymes break down the starch into fermentable sugars such as glucose, which are readily assimilated by fermentative microorganisms.Fermentation...
Cryptococcal Meningitis
Cryptococcal meningitis is a life-threatening opportunistic infection predominantly associated with HIV/AIDS, accounting for over 100,000 deaths annually worldwide. However, it also affects individuals with other forms of immunosuppression, including those undergoing immunosuppressive therapy, organ transplant recipients, patients with innate immunodeficiencies, and individuals with hematological disorders. The infection is caused mainly by Cryptococcus neoformans and Cryptococcus gattii,...

