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Updated: Jul 9, 2025

Three-dimensional Tissue Engineered Aligned Astrocyte Networks to Recapitulate Developmental Mechanisms and Facilitate Nervous System Regeneration
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糖原合成酶激酶3在神经再生中的信号传递 in vivo

Jing Zhang1, Shu-Guang Yang1, Feng-Quan Zhou1

  • 1Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, Hangzhou 310016, China.

Journal of molecular cell biology
|December 7, 2023
PubMed
概括

糖原合成酶激酶3 (GSK3) 信号传递对于神经系统中的神经发育和轴突再生至关重要. GSK3β通路调节蛋白质翻译和神经元基因表达,为神经修复提供潜在的治疗点.

关键词:
这是GSK3的GSK3.基因转录 基因转录神经再生的神经再生蛋白质翻译是蛋白质的翻译.

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Neurogenesis and Regeneration of Nervous Tissue01:15

Neurogenesis and Regeneration of Nervous Tissue

In the CNS, neurogenesis, the birth of new neurons from stem cells, is limited to the hippocampus in adults. In other regions of the brain and spinal cord, neurogenesis is almost non-existent due to inhibitory influences from neuroglia, especially oligodendrocytes, and the absence of growth-stimulating cues. The myelin produced by oligodendrocytes in the CNS inhibits neuronal regeneration. Furthermore, astrocytes proliferate rapidly after neuronal damage, forming scar tissue that physically...
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