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Updated: Jul 9, 2025

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如何调节器结合在粉样β-γ-分泌酶接口增强基质结合和减弱膜扭曲

Shu-Yu Chen1, Matthias Koch2, Lucía Chávez-Gutiérrez2

  • 1Center for Functional Protein Assemblies, Garching 85748, Germany.

Journal of medicinal chemistry
|December 7, 2023
PubMed
概括

γ-分泌酶调节剂 (GSM) 通过减少有毒的粉样β (Aβ) 来替代阿尔茨海默病的抑制剂. 这项研究揭示了像E2012这样的GSM如何与酶,基质和膜相互作用以达到这种效果.

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相关概念视频

Amyloid Fibrils03:03

Amyloid Fibrils

Amyloid fibrils are aggregates of misfolded proteins.  Under most circumstances, misfolded proteins are either refolded by chaperone proteins or degraded by the proteasome. However, in the case of a mutation or a disease, these proteins can accumulate to form large clusters and often further assemble to form elongated fibers, called fibrils. 
Amyloid deposits were observed as early as 1639 in the liver and the spleen.   In 1854, Rudolph Virchow performed iodine staining,...
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