微生物组:在免疫平衡和呼吸道炎症中起着不可或缺的作用
Olaf Perdijk1, Rossana Azzoni1, Benjamin J Marsland1
1Department of Immunology, School of Translational Science, Monash University, Melbourne, Victoria, Australia.
微生物组从婴儿期到成年期显著影响免疫和代谢健康. 了解这些宿主-微生物相互作用是预防和治疗喘和肺炎等疾病的关键.
科学领域:
- 微生物组研究的研究.
- 免疫学 免疫学 免疫学
- 呼吸系统药物 呼吸系统药物
背景情况:
- 微生物组在免疫和代谢平衡中起着至关重要的作用,特别是在妊娠和生命早期.
- 母亲因素和母乳影响婴儿的肠道殖民和免疫发育,影响对亚托皮性疾病和喘的易感性.
- 肺微生物组和吸入的微生物建立了肺免疫防御,但调节失调可能导致致病性细菌殖民和呼吸道疾病中的炎症.
研究的目的:
- 探索宿主微生物相互作用在呼吸道疾病中的作用.
- 为了确定疾病进展的潜在生物标志物.
- 研究微生物因素的治疗潜力.
主要方法:
- 对微生物组研究的审查,重点是免疫和代谢平衡.
- 在呼吸道疾病背景下对宿主微生物相互作用的分析.
- 探索关于微生物因素和多组学方法的临床前发现.
主要成果:
- 生命早期微生物组发育的干扰可能会使婴儿易患亚托皮性疾病和喘.
- 上呼吸道可以在患病状态下庇护病原体,导致肺炎.
- 腹腔肠道微生物及其产品可以保护人免受呼吸系统疾病.
结论:
- 在呼吸道疾病中研究宿主-微生物相互作用为患者分层和生物标志物发现提供了潜力.
- 来自开始性肠道微生物的微生物因素显示出在呼吸系统健康中临床应用的前景.
- 微生物组的多组学分析可以增强疾病管理的预测能力.
更多相关视频
06:43Studying Microbial Communities In Vivo: A Model of Host-mediated Interaction Between Candida Albicans and Pseudomonas Aeruginosa in the Airways
Published on: January 13, 2016
05:31Noninvasive Sampling of Mucosal Lining Fluid for the Quantification of In Vivo Upper Airway Immune-mediator Levels
Published on: August 7, 2017
相关概念视频
Defense Mechanism Against Infection
In addition, many body organ systems have unique defenses against infection. The skin is an intact, multilayered surface preventing invasion by microorganisms unless impaired. Mucous membranes lining the mouth, nose, and eyelids are barriers...
Anatomy of Respiratory System I: Upper Respiratory Tract
Nose and nasal cavity
The nose and nasal cavity represent the main external openings of the respiratory tract....
Bacterial Flora of the Large Intestine
The normal gut flora of the colon plays a critical role in generating essential vitamins such as vitamins K, B5, and B7.
Drugs Used in Lower Respiratory Disorders: Overview
Bronchodilators, the first step of respiration enhancement, come in various forms, each with its own mechanism...
Inflammatory Response
Inflammation can be triggered by various stimuli, such as impact, abrasion, chemical irritation, infections, and extreme hot or cold temperatures. These can damage cells and connective tissue fibers,...
Anatomy of the Intestines
Small Intestines
The small intestine is an ~7 meter-long tube with an inner diameter of just 2.5 cm. Since most nutrients are absorbed here, the inner lining of the...
