糖尿病前期和乳腺癌之间的关联:一个全面的元分析
Praneeth Reddy Keesari1, Akhil Jain2, Narendranath Reddy Ganampet3
1Department of Internal Medicine, Staten Island University Hospital, Staten Island, NY, USA.
Breast cancer research and treatment
|December 7, 2023
概括
糖尿病前期增加乳腺癌的风险,特别是在年轻人中. 对糖尿病前期的早期监测和干预可以帮助降低这种风险.
科学领域:
- 在瘤学瘤学.
- 内分泌学 在内分泌学.
- 代谢健康 代谢健康
背景情况:
- 乳腺癌是女性的主要癌症,糖尿病被认为是危险因素.
- 糖尿病前期和乳腺癌风险之间的关联是有争议的,有相互矛盾的证据.
- 这一元分析旨在澄清糖尿病前期和乳腺癌发病率之间的关系.
研究的目的:
- 评估与正常血糖症患者相比,糖尿病前期患者的乳腺癌风险.
- 调查这种关联的潜在改变因素,如年龄和随访持续时间.
主要方法:
- 在主要数据库 (PubMed/Medline,EMBASE,Google Scholar,Scopus) 中进行了系统的文献搜索.
- 使用二进制随机效应模型计算95%置信区间的聚合赔率比率 (OR).
- 使用I2统计数据评估异质性,并进行敏感性和子组分析.
主要成果:
- 分析了7项涉及24,586名糖尿病前期患者和224,314名正常血糖患者的研究.
- 前糖尿病与乳腺癌的调整几率比率增加有关 (1.19; 95% CI: 1.071.34).
- 在60岁以下的个体 (OR=1.86) 和较短的随访期 (≤2年,OR=2.34) 中观察到更高的风险.
结论:
- 与正常血糖水平相比,糖尿病前期患者患乳腺癌的风险较高.
- 在年轻的糖尿病前期患者和研究后续持续时间较短的患者中,风险明显更高.
- 建议对受影响的个体进行早期识别,监测和干预以逆转糖尿病前期.
相关概念视频
Psychoneuroimmunology: Diabetes and Cancer
29
Chronic stress has been linked to both the onset and progression of serious health conditions, including Type 2 diabetes and cancer. Type 2 diabetes, a widespread chronic illness, is closely associated with obesity and insulin resistance, both of which often worsen under stress. Studies indicate that men experiencing high levels of chronic stress face a 45% higher risk of developing diabetes compared to those with minimal stress. Stress triggers physiological responses that elevate blood...
29
Pathophysiology of Diabetes
950
Diabetes mellitus is a chronic metabolic disorder characterized by hyperglycemia. The four categories of diabetes are type 1 diabetes, type 2 diabetes, other specific types of diabetes, and gestational diabetes.
Type 1 diabetes is characterized by autoimmune-mediated destruction of pancreatic β cells, with environmental factors potentially triggering this process in genetically susceptible individuals. Despite many not having a family history, certain genes increase susceptibility,...
Type 1 diabetes is characterized by autoimmune-mediated destruction of pancreatic β cells, with environmental factors potentially triggering this process in genetically susceptible individuals. Despite many not having a family history, certain genes increase susceptibility,...
950
Diabetes Mellitus: Type 2 and Gestational
2.4K
Type 2 diabetes, characterized by insulin resistance, arises when the insulin receptors on cells lose responsiveness to insulin, diminishing the cell's capacity to take up glucose, resulting in elevated blood glucose levels. To receive a diagnosis of Type 2 diabetes, a series of blood glucose tests are necessary to assess whether the blood glucose falls within normal parameters. If the result is out of the normal range, a patient may be diagnosed as prediabetic or diabetic, depending on the...
2.4K
Cancer Prevention
6.2K
Several factors can increase the risk of cancer in an individual. About 50% of cancer cases can be prevented by adopting a healthy lifestyle, regular exercise, eating healthy, and following a modest cancer prevention diet. Epidemiological studies have consistently shown that populations with vegetable and fruit-rich diets have reduced the incidence of cancer. On the other hand, populations who have a diet rich in animal fat, red meat, junk food, or high calories are predisposed to cancer.
Some...
Some...
6.2K
Cancer Survival Analysis
356
Cancer survival analysis focuses on quantifying and interpreting the time from a key starting point, such as diagnosis or the initiation of treatment, to a specific endpoint, such as remission or death. This analysis provides critical insights into treatment effectiveness and factors that influence patient outcomes, helping to shape clinical decisions and guide prognostic evaluations. A cornerstone of oncology research, survival analysis tackles the challenges of skewed, non-normally...
356
Diabetes: Symptoms, Diagnosis, and Complications
554
For most patients, experiencing several weeks of polyuria, polydipsia, fatigue, and significant weight loss may indicate the presence of diabetes. Furthermore, adults displaying the phenotypic appearance of type 2 diabetes (particularly those who are obese and not initially insulin-requiring), may have islet cell autoantibodies, suggesting autoimmune-mediated β cell destruction and a diagnosis of latent autoimmune diabetes of adults (LADA). The categorization of glucose homeostasis is...
554


