根据种族和种族,按人口归因的晚期乳腺癌风险
Karla Kerlikowske1,2, Shuai Chen3, Michael C S Bissell3,4
1Departments of Medicine and Epidemiology and Biostatistics, University of California, San Francisco.
JAMA oncology
|December 7, 2023
概括
超重/肥胖和乳腺密度显著导致晚期乳腺癌风险,特别是在黑人和亚洲女性. 专注于体重管理的初级预防对于减少晚期乳腺癌诊断至关重要.
科学领域:
- 在瘤学瘤学.
- 公共卫生 公共卫生
- 流行病学 流行病学
背景情况:
- 晚期乳腺癌发病率不成比例地影响黑人女性与白人女性相比.
- 在晚期乳腺癌中导致这些种族差异的临床风险因素在很大程度上仍未确定.
研究的目的:
- 为了确定人口可归因风险比例 (PARP) 对于晚期乳腺癌.
- 评估临床风险因素与不同种族,种族和更年期状态的晚期乳腺癌的相关性.
主要方法:
- 一项前性队列研究分析了2005年至2018年间接受查性乳房造影的904,615名40-74岁妇女的数据.
- 评估的风险因素包括乳腺密度,家族病史,超重/肥胖 (BMI>25.0),先前的良性乳腺活检和查间隔.
- 分析按更年期状态和种族/种族分层 (亚洲/太平洋岛民,黑人,西班牙裔/拉丁裔,白人,其他/多种族).
主要成果:
- 超重/肥胖在绝经后女性 (30%) 和绝经前女性 (22%) 中占了较高的PARP,黑人和西班牙裔/拉丁裔女性的负担最高.
- 密集的乳房代表了更大的PARP在绝经前妇女 (37%) 与绝经后妇女 (24%),特别是影响亚洲/太平洋岛屿和白人妇女.
- 家庭病史,先前活检和查间隔在所有组中对晚期乳腺癌风险的贡献最小.
结论:
- 虽然查间隔的影响很小,但超重/肥胖和乳腺密度是晚期乳腺癌的重要,可修改的风险因素.
- 有针对性的初级预防策略,特别是体重管理干预措施,对于减少晚期乳腺癌诊断至关重要,特别是在高风险的种族和民族群体中.
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