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相关概念视频

External Anatomy of the Kidney01:21

External Anatomy of the Kidney

1.1K
The kidneys are a pair of bean-shaped organs in the human body that play a critical role in maintaining overall health. They filter out waste products from the blood, regulate blood pressure, maintain electrolyte balance, and stimulate the production of red blood cells.
The kidneys are located in the retroperitoneal space on either side of the vertebral column, protected posteriorly by the 11th and 12th ribs. The right kidney sits slightly lower than the left owing to the presence of the liver...
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Internal Anatomy of the Kidney01:12

Internal Anatomy of the Kidney

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The kidneys are essential organs in the human body, performing a myriad of tasks that maintain homeostasis and overall health.
Anatomical Position and Dimensions
The kidneys are retroperitoneal organs positioned against the posterior abdominal wall on either side of the spine, roughly between the twelfth thoracic and third lumbar vertebrae. Each kidney is typically 10-12 cm long, 5-6 cm wide, and 3-4 cm thick, weighing about 150 grams.
Renal Cortex
The outermost region of the kidney is the...
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Kidney Structure01:45

Kidney Structure

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The kidneys are two large bean-shaped organs located in the upper abdomen. They filter the blood several times a day to remove toxins and rebalance water and electrolytes of the circulatory system via the renal veins. The kidneys receive blood directly from the heart via the renal arteries. These arteries enter the kidney at the hilum, the concave surface of the bean, where they branch and divide into smaller vessels and capillaries.
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相关实验视频

Updated: Jul 9, 2025

Author Spotlight: Developing a Bedside Protocol for Kidney and Genitourinary Ultrasonography
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在脏发育过程中,几何效应将囊置于脏的位置上.

Malte Mederacke1, Lisa Conrad2, Nikolaos Doumpas1

  • 1Department of Biosystems Science and Engineering, ETH Zürich, Schanzenstrasse 44, 4056 Basel, Switzerland; Swiss Institute of Bioinformatics, Mattenstrasse 26, 4058 Basel, Switzerland.

Cell reports
|December 7, 2023
PubMed
概括

几何效应将WNT9b信号集中在尿道芽结处,指导脏发育和脏定位. 这种机制解释了囊在分支收集管道附近如何形成.

关键词:
CP: 发育生物学计算建模计算建模照明表显微镜 显微镜脏的发育 脏的发育

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科学领域:

  • 发展生物学 发展生物学
  • 计算生物学 计算生物学
  • 脏生理学 脏生理学

背景情况:

  • 脏发育涉及表皮和介质细胞之间复杂的信号传输.
  • 与收集管子分支相对而言,脏细胞的确切位置尚不清楚.

研究的目的:

  • 阐明脏器官生成过程中脏囊泡定位的机制.
  • 了解WNT9b信号如何影响脏形成和收藏管分支.

主要方法:

  • 使用了计算建模和实验方法的组合.
  • 研究了几何效应在聚焦信号分子中的作用.

主要成果:

  • 证明了几何效应将WNT9b集中在尿道芽分支的结点上.
  • 表明WNT9b度驱动囊的出现和脏形成.
  • 鉴定出这种机制即使在尿道上皮质中具有均的WNT9b表达,也能发挥作用.

结论:

  • 几何效应对于在发育过程中创建信号梯度至关重要.
  • 这种通过曲线传递局部信号的机制可能是发育生物学中的一般原则.