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相关概念视频

T Cell Activation and Clonal Selection01:22

T Cell Activation and Clonal Selection

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T cells are integral to our adaptive immune system, recognizing and effectively responding to foreign antigens. T cell activation and clonal selection are pivotal in orchestrating this immune response. This article elucidates these mechanisms, detailing the roles of cluster of differentiation (CD) markers, major histocompatibility complex (MHC) molecules, costimulatory signals, and the process of clonal selection.
Naive T cells that have not yet encountered an antigen express two primary CD...
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B Cell Activation and Differentiation01:24

B Cell Activation and Differentiation

1.7K
The adaptive immune response, a sophisticated defense mechanism, relies on the activation and differentiation of B lymphocytes, or B cells. These processes enable our bodies to mount a tailored response against specific pathogens such as bacteria, free virus particles, toxins, and parasites.
When naive B cells encounter a specific antigen that can bind to the B cell receptor (BCR) on their surface, they undergo sensitization to respond to the antigen's presence. Sensitization begins with...
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Cells of the Adaptive Immune Response01:23

Cells of the Adaptive Immune Response

994
The T and B lymphocytes of the adaptive immune system develop from common lymphoid progenitor cells in the bone marrow. These progenitors give rise to precursors that eventually develop into both T and B lymphocytes. As these precursors mature, they gain the ability to detect and respond to foreign antigens in the body, a process known as immunocompetence. Additionally, these precursors acquire self-tolerance, a process that ensures they do not react to self-antigens. This intricate system...
994
Special Features of Adaptive Immunity01:20

Special Features of Adaptive Immunity

833
The adaptive immune system, a crucial component of the overall immune response, offers a highly specialized defense against pathogens. It involves specific cell types and features, enabling it to combat infections effectively and efficiently.
The primary cell types involved in adaptive immunity are T cells and B cells. Each type has a unique role in defending the body against pathogens. T cells are responsible for cell-mediated immunity. They identify and eliminate infected cells directly,...
833
Diversity of Antigen Receptors01:28

Diversity of Antigen Receptors

595
Antigen receptors are essential components of the immune system crucial in defending the body against foreign invaders. These receptors are present on the surface of B and T cells, enabling them to recognize antigens and mount an appropriate immune response.
Before encountering any antigen, lymphocytes express these receptors. On B cells, the antigen receptor is a membrane-bound antibody molecule called BCR; on T cells, it is a T cell receptor or TCR. B and T cell receptors are composed of two...
595
T Cell Types and Functions01:24

T Cell Types and Functions

1.0K
When T cells with CD4 markers are activated, they give rise to two types of effector cells: helper T cells and regulatory T cells. Meanwhile, T cells with CD8 markers differentiate into effector cytotoxic T cells. The differentiation of CD4 T cells into helper T cell subsets, such as Th1, Th2, and Th17 cells, is dependent on the antigen type, antigen-presenting cell, and regulatory cytokines.
Th1 cells stimulate dendritic cells to express necessary co-stimulatory molecules on their surfaces for...
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相关实验视频

Updated: Jul 9, 2025

The Isolation, Differentiation, and Quantification of Human Antibody-secreting B Cells from Blood: ELISpot as a Functional Readout of Humoral Immunity
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The Isolation, Differentiation, and Quantification of Human Antibody-secreting B Cells from Blood: ELISpot as a Functional Readout of Humoral Immunity

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CD62L表达标志着一个功能上不同的记忆B细胞子集.

Christopher H Hanson1, Brittany Henry1, Pradhnesh Andhare1

  • 1Department of Medicine, Washington University School of Medicine, St. Louis, MO, USA.

Cell reports
|December 7, 2023
PubMed
概括

记忆B细胞子集是不同的,并由特定的基因调节. 在SARS-CoV-2疫苗接种后,CD62L表达识别了这些功能上不同的小鼠和人类群体.

关键词:
B 细胞 B 细胞 B 细胞CP: 免疫学 免疫学幽默免疫力 幽默免疫力免疫学记忆是一种免疫学记忆.

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Discrimination of Seven Immune Cell Subsets by Two-fluorochrome Flow Cytometry
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Discrimination of Seven Immune Cell Subsets by Two-fluorochrome Flow Cytometry

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Flow Cytometric Characterization of Murine B Cell Development
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Flow Cytometric Characterization of Murine B Cell Development

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相关实验视频

Last Updated: Jul 9, 2025

The Isolation, Differentiation, and Quantification of Human Antibody-secreting B Cells from Blood: ELISpot as a Functional Readout of Humoral Immunity
08:26

The Isolation, Differentiation, and Quantification of Human Antibody-secreting B Cells from Blood: ELISpot as a Functional Readout of Humoral Immunity

Published on: December 14, 2016

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Discrimination of Seven Immune Cell Subsets by Two-fluorochrome Flow Cytometry
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Discrimination of Seven Immune Cell Subsets by Two-fluorochrome Flow Cytometry

Published on: March 5, 2019

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Flow Cytometric Characterization of Murine B Cell Development
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科学领域:

  • 免疫学 免疫学 免疫学
  • 细胞生物学 细胞生物学
  • 分子生物学分子生物学

背景情况:

  • 记忆B细胞反应涉及不同的子集,具有不同的抗原反应性.
  • 控制记忆B细胞子集发展和功能的途径在很大程度上仍然不清楚.

研究的目的:

  • 研究记忆B细胞子集分化的调节机制.
  • 为了识别区分功能上不同的记忆B细胞子集的标记.

主要方法:

  • 在小鼠记忆B细胞中分析CD62L和CD44的表达.
  • 研究Bcl6和Zeb2在B细胞亚群发育中的作用.
  • 检查SARS-CoV-2疫苗接种后人类B细胞记忆中的CD62L表达.

主要成果:

  • 在小鼠记忆B细胞中,CD62L和CD44的表达逐渐增加,定义了不同的子集.
  • Bcl6对于记忆B细胞子集分化至关重要;其过度表达会损害CD62L+记忆B细胞的发育.
  • Bcl6调节像Bcl2和Zeb2这样的基因;Zeb2的过度表达也阻碍了CD62L+记忆B细胞的发展.
  • 在SARS-CoV-2疫苗接种后,CD62L在人类记忆B细胞上有差异表达,识别出不同的种群.

结论:

  • CD62L表达作为功能上不同的记忆B细胞子集的标记.
  • 这些发现阐明了记忆B细胞子集发展和功能的关键调节者.
  • CD62L在区分记忆B细胞子集中的作用在物种之间得到保护,并且与疫苗反应相关.