实地研究检查马体腺胃病中的粘膜微生物组
Linda J Paul1, Aaron C Ericsson2, Frank M Andrews1
1Veterinary Clinical Sciences, Equine Health and Sports Performance, Louisiana State University, Baton Rouge, LA, United States of America.
PloS one
|December 7, 2023
概括
马腺胃病 (EGGD) 与胃的变化有关.
科学领域:
- 兽医医学 兽医医学 兽医医学
- 马的健康 马的健康
- 微生物组研究 微生物组研究
背景情况:
- 马腺胃病 (EGGD) 在运动马中普遍存在,影响其健康和表现.
- EGGD的根本原因和机制尚未完全理解.
- 之前的研究表明,胃腺粘膜微生物组与EGGD之间存在联系.
研究的目的:
- 为了在不同的管理环境中比较具有和没有EGGD的马的胃微生物群.
- 调查EGGD的潜在风险因素,包括饮食和管理实践.
- 测试胃腺粘膜微生物组的变化与EGGD相关的假设.
主要方法:
- 微生物种群从正常的甲状腺粘膜 (没有EGGD的马),正常的甲状腺粘膜 (患有EGGD的马) 和受损的腺体粘膜 (患有EGGD的马) 的活检中分析.
- 在收集的微生物样本上进行了社区结构分析.
- 为了进行风险因素分析,收集了饮食和管理数据.
主要成果:
- 在病变活检 (EGGD) 和对照活检 (没有EGGD) 之间,在微生物群体结构中观察到显著的差异.
- 对照活检显示了Actinomycetota类的较高丰富性,以及Staphylococcus,Lawsonella和Streptococcus salivarius的丰富性.
- 损伤活检显示了Lactobacillus和Actinobacillus属以及Lactobacillus equigenerosi物种的丰富. 每周的运动持续时间被确定为一个危险因素.
结论:
- 这项研究表明,在患有EGGD的马的粘膜部位和没有EGGD的马的正常的甲状腺粘膜之间,在胃腺微生物组中存在明显的差异.
- 这些发现支持了胃腺微生物组的变化与EGGD相关的假设.
- 增加运动时间是发展EGGD的一个潜在风险因素.
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