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基于细菌纤维素的带带有集成的抗菌和电刺激,用于高级伤口管理

Xiaohao Liu¹, Zhuyun Cai², Manman Pei¹

¹Department of Orthopaedics, Center for Orthopaedic Science and Translational Medicine, Shanghai Tenth People's Hospital, School of Medicine, Tongji University, 301 Yanchang Road, Shanghai, 200072, P. R. China.

Advanced healthcare materials

|December 7, 2023

概括

带有银纳米线的新型细菌纤维素带提供先进的伤口愈合和监测. 这些智能带促进了更快的皮肤修复,并准确地跟踪愈合阶段,解决了传统伤口护理的局限性.

科学领域:

生物材料科学生物材料科学
再生医学是一种再生医学.
纳米技术纳米技术

背景情况:

传统的带在外观,舒适性,功能和环境影响方面都有局限性.
细菌纤维素 (BC) 为先进的伤口带提供了一个有前途的基础.
需要智能带,可以监测伤口愈合并提供治疗效益.

研究的目的:

开发新的基于细菌纤维素 (BC) 的带,用于伤口监测和先进的伤口管理.
创建具有抗菌和导电性质的超薄,透气和机械坚固的BC / AgNW带.
通过电刺激和监测愈合阶段,评估BC/AgNW带在促进伤口愈合方面的有效性.

主要方法:

使用真空过方法制造BC/AgNW复合膜.
带的特性:透明度,厚度,透气性,机械强度,抗菌活性和导电性.
使用电刺激在老鼠全厚皮肤缺陷上的体内研究.
开发和应用卷积神经网络用于伤口愈合阶段的分类.

主要成果:

开发了透明,超薄 (≈7微米),透气,机械上优越的BC/AgNW带.
显示出对大肠杆菌和黄金杆菌有显著的抗菌活性.
用BC/AgNW带进行电刺激,通过增加VEGF分泌,促进了大鼠的伤口愈合.
通过使用BC带和CNN来分类伤口愈合阶段,获得了94.7%的准确性.

结论:

BC/AgNW带是用于先进的伤口管理和监测的多功能材料.
使用这些智能带的电刺激显著提高了皮肤缺陷的修复.
开发的基于BC的带为下一代智能伤口护理解决方案提供了新的策略.

关键词:

细菌纤维素的细菌纤维素.带带带带电刺激是一种电刺激.监控监控监控监控监控监控伤口愈合伤口愈合

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