夜间德甲抑制试验与衰老之间的关系
Serpil Ciftel1, Filiz Mercantepe2
1Department of Endocrinology and Metabolism, Faculty of Medicine, Erzurum Regional Training and Research Hospital, Erzurum, TUR.
Cureus
|December 7, 2023
概括
在1毫克德甲抑制试验 (DST) 后,衰老与更高的皮质醇水平正相关. 这表明下丘脑-垂体-上腺 (HPA) 轴.
科学领域:
- 内分泌学 在内分泌学.
- 老年医学 老年医学
- 激素研究 研究 激素研究
背景情况:
- 下垂体-垂体-上腺 (HPA) 轴调节皮质醇的产生.
- 衰老可能会改变HPA轴活动和皮质醇反机制.
- 1毫克德克萨米他抑制试验 (DST) 用于评估高皮质醇血症.
研究的目的:
- 为了研究年龄和抑制的皮质醇水平之间的关系后-1-mg DST.
- 为了确定衰老是否影响HPA轴的负反调节.
主要方法:
- 对1111名成年人 (≥18岁) 的1毫克DST结果进行了回顾性分析.
- 参与者患有上腺瘤或疑似高皮质血症.
- 在四个年龄组中进行了年龄相关性相关性分析.
主要成果:
- 在年龄和DST后皮质醇水平之间发现了强烈的正相关性.
- 在不同年龄组中观察到DST后皮质醇水平的显著差异 (p=0.000).
- 在DST后,皮质醇的中位数总体为18.49nmol/L.
结论:
- 在老年人中,皮质醇负反机制可能会受到损害.
- 1毫克的DST可能会在老年人中产生更高的错误阳性率.
- 年龄是影响DST结果的重要因素,可疑高皮质素血症.
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