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Updated: Jul 9, 2025

A Package of Established Analytical Tools to Investigate the Solid-State Alteration of Lipid-Based Excipients
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用加速稳定性评估程序建模预测口服输送抗体药物产品的长期稳定性

Lulu Dai1, Jeff Davis1, Karthik Nagapudi1

  • 1Synthetic Molecule Pharmaceutical Science, Early Research and Development, Genentech, South San Francisco, California 94080, United States.

Molecular pharmaceutics
|December 7, 2023
PubMed
概括

这项研究评估了口服蛋白质疗法的稳定性,特别是重链抗体 (VHH抗体) 药物产品的可变域. ASAPprime软件准确预测了蛋白质的稳定性,突出了口服生物药物开发的新方法.

关键词:
加快稳定性评估计划这就是VHH VHH.通过口服输送的蛋白质是通过口服输送的.蛋白质聚合蛋白质的聚合物固态状态的固态状态.稳定的稳定性 稳定的稳定性

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