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整个心血管风险谱的肠道微生物组
Femke M Prins1,2, Valerie Collij1, Hilde E Groot2
1University of Groningen, University Medical Center Groningen, Department of Gastroenterology and Hepatology, Groningen, The Netherlands.
European journal of preventive cardiology
|December 7, 2023
概括
肠道微生物组的改变与心血管风险和ST升高心肌梗塞 (STEMI) 有关. 随着心血管风险的增加,特定的细菌物种和代谢途径发生变化,为预防心脏病提供了潜在的新治疗点.
科学领域:
- 微生物组研究的研究.
- 心血管疾病是什么心血管疾病
- 转基因组学是指转基因组学.
背景情况:
- 心血管疾病 (CVD) 是全球主要的死亡原因.
- 人们越来越认识到肠道微生物在心血管疾病 (CVD),包括冠状动脉疾病 (CAD) 中的作用.
- 对于CAD发育过程中的特定肠道微生物组转变以及不同心血管风险水平的理解有限.
研究的目的:
- 研究不同心血管风险的个体的肠道微生物组变化.
- 描述ST升高心肌梗塞 (STEMI) 患者的微生物组变化.
- 确定与心血管风险和STEMI相关的微生物物种和代谢途径.
主要方法:
- 横截面研究分析411个便样本使用metagenomics.
- 参与者根据Framingham分数和STEMI患者的心血管风险 (低,中等,高) 分类.
- 分析微生物多样性,物种丰富性和功能途径,控制混因素.
主要成果:
- 四种微生物物种 (Collinsella stercoris,Flavonifractor plautii,Ruthenibacterium lactatiformans) 呈现出与心血管风险相关的丰度增加.
- 热杆菌 (Streptococcus thermophilus) 的丰富性与心血管风险有负面关联.
- STEMI患者表现出维生素,脂质和氨基酸生物合成的肠道微生物群途径枯竭.
结论:
- 确定了特定的微生物物种,其丰度趋势与心血管风险进展相关.
- 与非CAD患者相比,在STEMI患者中观察到不同的微生物物种和代谢途径.
- 这些发现突出了对CAD进展和预防的潜在新型治疗点.
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