特拉斯图苏马布德鲁克斯泰康-相关的间歇性肺病/肺炎:计算机断层扫描成像模式,以指导诊断和管理
Mizuki Nishino1, Masahiko Kusumoto2, Alexander A Bankier3
1Department of Radiology, Brigham and Women's Hospital and Dana-Farber Cancer Institute, Boston, MA.
特拉斯图祖马布德鲁克斯泰肯 (T-DXd) 肺炎通常表现为密码性组织性肺炎 (COP) 模式. 急性间歇性肺炎 (AIP) /急性呼吸困难综合征 (ARDS) 模式表明严重的,致命的肺损伤需要紧急注意.
科学领域:
- 在瘤学瘤学.
- 肺部病理学 肺部病理学
- 放射学 放射学是一门学科.
背景情况:
- 特拉斯图祖马布德鲁克斯泰坎 (T-DXd) 是一种用于治疗晚期癌症的抗体药物联合体.
- 严重或致命的间歇性肺病/肺炎是与T-DXd治疗相关的已知风险.
研究的目的:
- 为了描述T-DXd相关肺炎的计算机断层扫描 (CT) 模式.
- 为了将CT模式与临床严重程度和患者结果相关联.
主要方法:
- 对90名T-DXd相关肺炎患者的CT扫描进行分析.
- 三名放射科医生对CT图案进行独立审查.
- CT发现与临床严重程度 (CTCAE等级) 和结果的相关性.
主要成果:
- 最常见的CT模式是密码性组织性肺炎 (COP) (72%).
- 一组COP病例的子集显示出不典型的上/外周肺部参与.
- 急性间歇性肺炎 (AIP) /急性呼吸困难综合征 (ARDS) 模式与更高的严重程度 (P < .0001),增加的死亡率 (P = .005) 和早期发病 (P = .019) 相关.
结论:
- T-DXd肺炎通常呈现出COP模式,有时不典型.
- 在AIP/ARDSCT模式表示严重的,可能致命的肺炎.
- 及时的临床识别和干预对于管理T-DXd相关的肺炎至关重要.
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