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在自身免疫性甲状腺疾病中进行甲状腺切除术的术前医学治疗的结果
Signe M Braafladt1, Timothy C Baumgartner2, Hannah R Allison1
1Department of Surgery, Indiana University School of Medicine, Indianapolis, Indiana.
The Journal of surgical research
|December 7, 2023
概括
在接受甲状腺切除术的自身免疫性甲状腺疾病 (AITD) 患者中,手术前使用皮质类固醇并没有增加手术并发症. 虽然早期的术后水平略低,但甲状腺功能障碍率保持不变,这表明AITD管理的安全选择.
科学领域:
- 内分泌学 在内分泌学.
- 手术瘤学手术瘤学
- 免疫学 免疫学 免疫学
背景情况:
- 甲状腺切除术是对自身免疫性甲状腺疾病 (AITD) 的绝对治疗方法,可以改善生活质量.
- 从历史上看,接受甲状腺切除术的AITD患者面临着较高的hypoparathyroidism风险和复发的喉神经麻.
- 研究手术前药物影响对于优化AITD手术结果至关重要.
研究的目的:
- 评估手术前药物的结果,特别是酸和酸盐和皮质类固醇的和溶液 (SSKI),在接受甲状腺切除术的AITD患者中.
- 分析术前医疗治疗与手术并发症 (包括小甲状腺功能低下和神经损伤) 之间的关联.
- 评估术前皮质类固醇对术后实验室值和手术结果的影响.
主要方法:
- 在2015年至2021年期间为AITD进行了甲状腺切除术的123名患者的回顾性分析.
- 基于手术前药物的患者分类:没有,SSKI,皮质类固醇,或两者兼而有之.
- 分析手术结果 (输血,手术时间,并发症) 和术后实验室值 (水平).
主要成果:
- 在接受手术前皮质类固醇和未接受皮质类固醇的患者之间,没有观察到血液损失,手术时间或神经损伤的显著差异.
- 接受皮质类固醇治疗的患者和那些患有格雷夫斯病的患者显示,早期术后低血症的发病率较高 (术后1日<8.5 mg/dL).
- 在所有治疗组中,暂时性或永久性甲状腺功能低下的发病率没有显著差异.
结论:
- 在接受甲状腺切除术的AITD患者中,术前使用皮质类固醇与手术并发症的风险增加无关.
- 虽然皮质类固醇可能导致轻度过渡性低血症,但它们不会增加缺甲状腺症的风险.
- 需要进一步的研究来探索手术前皮质类固醇对AITD患者手术困难,生活质量和自身抗体清除的影响.
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