D-Dimer趋势预测癌症相关的高凝血性患者的复发性中风
Jun Fujinami1, Yoshinari Nagakane2, Kei Fujikawa3
1Department of Neurology, Kyoto Second Red Cross Hospital, Kyoto, Japan, jun2473@gmail.com.
Cerebrovascular diseases extra
|December 7, 2023
概括
抗凝药治疗后D-二聚物水平升高表明,癌症相关高凝度 (CAH) 相关的中风患者中,复发性中风的风险更高. 监测D-二次体趋势可以帮助识别高风险个体.
科学领域:
- 神经学 神经学
- 在瘤学瘤学.
- 血液学 血液学 血液学
背景情况:
- 与癌症相关的高凝血性 (CAH) 增加了中风风险.
- 抗凝固药治疗后的D-二聚体趋势可能预测CAH相关中风的治疗疗效.
- 复发性中风是这些患者的一个重大问题.
研究的目的:
- 调查CAH相关中风患者中D-二次体趋势和复发性中风之间的关联.
- 为了确定抗凝剂治疗后的D-二聚物水平是否可以作为治疗反应的生物标志物.
主要方法:
- 73名CAH相关中风患者 (2011-2020) 的回顾性队列研究.
- 用于评估趋势的D-二次元治疗前后比率.
- 细灰模型分析了D-二次数比率与复发性中风之间的关联.
主要成果:
- 在28天的中位数随访期间,18%的患者出现了复发性中风.
- 一个高的后/前D-二分体比率独立地与复发性中风的风险增加有关 (HR 2.20).
结论:
- 抗凝固药治疗后的D-二次体趋势与CAH相关的中风患者中风复发风险有关.
- 治疗后持续高D-二聚物水平的患者面临中风复发的风险增加.
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