系统性硬化症的流媒体扩张:与临床发现,毛细管学模式和内皮循环标记物的关联
Addolorata Corrado1, Natalia Mansueto1, Michele Correale2
1Rheumatology Clinic, Department of Medical and Surgical Sciences, University of Foggia, Viale Pinto 1, Foggia, Italy.
Vascular pharmacology
|December 7, 2023
概括
系统性硬化症患者表现出内皮功能障碍,由较低的流媒扩张 (FMD) 和较高的血管标记物表明. 这些口病损伤与疾病严重程度和并发症相关,突出显示口病和评估SSc血管病变的生物标志物.
科学领域:
- 心血管医学 心血管医学
- 类风湿病学 类风湿病学
- 血管生物学 血管生物学
背景情况:
- 内皮功能障碍是系统性硬化症 (SSc) 血管损伤的核心原因.
- 了解SSc病理生理学需要评估内皮功能和相关生物标志物.
- 在SSc患者中,微血管和宏血管并发症是显著的.
研究的目的:
- 在SSc中使用流媒扩张 (FMD) 评估内皮功能障碍.
- 测量主要内皮功能障碍标记物的血清水平:血管内皮生长因子 (VEGF),血管细胞粘附分子-1 (VCAM-1) 和血管蛋白-2.
- 为了将宏血管损伤与SSc.中的临床发现和微血管模式相关联.
主要方法:
- 招募了57名SSc患者和37名健康对照.
- 进行了放射性动脉口病检测和指甲视频毛细血管镜检测.
- 评估了VEGF,VCAM-1和血管蛋白-2的血清水平.
主要成果:
- 与对照组相比,SSc患者表现出明显较低的口病和较长的时间到最大的口病反应.
- 在SSc患者中,VEGF,VCAM-1和血管蛋白-2的血清水平显著升高.
- 受损的口病与疾病持续时间,肺动脉高血压,数字和微血管损伤相关. 在患有数字和肺动脉高血压的患者中,VEGF和血管蛋白-2的含量较高.
结论:
- 流媒扩张 (FMD) 超声波和循环内皮功能障碍标记物显示出SSc.中血管病变的生物标记物的潜力.
- 这些评估可以帮助评估系统性硬化症患者的血管损伤.
- 结合口病和生物标志物分析,提供了一种全面的方法来了解SSc血管并发症.
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