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相关概念视频

Antibody Structure01:10

Antibody Structure

60.2K
Overview
Antibodies, also known as immunoglobulins (Ig), are essential players of the adaptive immune system. These antigen-binding proteins are produced by B cells and make up 20 percent of the total blood plasma by weight. In mammals, antibodies fall into five different classes, which each elicits a different biological response upon antigen binding.
The Y-Shaped Structure of Antibodies Consists of Four Polypeptide Chains
Antibodies consist of four polypeptide chains: two identical heavy...
60.2K
Antibody Structure and Classes01:25

Antibody Structure and Classes

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Antibodies, also known as immunoglobulins, are produced by B cells in response to foreign substances, such as bacteria and viruses. These proteins are critical for recognizing and neutralizing these substances, protecting the body from potential harm.
The basic structure of an antibody consists of four protein chains: two identical heavy chains and two identical light chains. These chains are held together by disulfide bonds and other non-covalent interactions, forming a Y-shaped structure.
919
Antibody Actions01:26

Antibody Actions

1.1K
Antibodies, or immunoglobulins, are critical players in the immune system's arsenal against invading pathogens. Produced by B cells and plasma cells, their primary role is to detect and bind to specific antigens, molecules found on the surface of pathogens like bacteria or viruses. Beyond antigen recognition, antibodies perform several vital functions that contribute to immune defense.
Neutralization
Antibodies can bind to pathogens, preventing them from infecting host cells. This process...
1.1K
Diversity of Antigen Receptors01:28

Diversity of Antigen Receptors

595
Antigen receptors are essential components of the immune system crucial in defending the body against foreign invaders. These receptors are present on the surface of B and T cells, enabling them to recognize antigens and mount an appropriate immune response.
Before encountering any antigen, lymphocytes express these receptors. On B cells, the antigen receptor is a membrane-bound antibody molecule called BCR; on T cells, it is a T cell receptor or TCR. B and T cell receptors are composed of two...
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相关实验视频

Updated: Jul 9, 2025

High-resolution Melting PCR for Complement Receptor 1 Length Polymorphism Genotyping: An Innovative Tool for Alzheimer's Disease Gene Susceptibility Assessment
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识别和结构分析二维补充成分3d及其与补充受体2的结合.

Huan Jin1, Min Tu1, Zhaoying Meng2

  • 1Institute of Animal Husbandry and Veterinary Medicine, Beijing Academy of Agriculture and Forestry Sciences, Beijing, People's Republic of China.

Developmental and comparative immunology
|December 7, 2023
PubMed
概括

补充成分3d (C3d) 形成二元体,增强其与CR2 (chCR2) 的相互作用. 这种二分化是免疫系统的关键.

关键词:
肉补充成分 3d 部分补体受体2 补体受体2迪默 (Dimer) 是一个数字.同源的建模同源的建模.分子对接是分子对接.表面等离子体共振是什么?

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Targeted Antibody Blocking by a Dual-Functional Conjugate of Antigenic Peptide and Fc-III Mimetics DCAF
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Measuring Erythrocyte Complement Receptor 1 Using Flow Cytometry

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科学领域:

  • 免疫学 免疫学 免疫学
  • 生物化学 生物化学
  • 分子生物学分子生物学

背景情况:

  • 补充成分3d (C3d) 通过与CR2相互作用,将先天性和适应性免疫联系在一起.
  • 与其单体形式相比,双体人体C3d显示了增强的功能.
  • 在C3d (chC3d) 中二元化的作用及其与CR2 (chCR2) 的相互作用仍然未被探索.

研究的目的:

  • 为了调查C3d (chC3d) 是否表现出二分化.
  • 为了确定二度chC3d是否与CR2 (chCR2) 结合.
  • 阐明chC3d和chCR2之间的相互作用机制.

主要方法:

  • 同免疫沉和共聚焦显微镜评估chC3d的自我相互作用和同定位.
  • 原生聚烯胺凝电泳和西部涂抹用于二维chC3d检测.
  • 表面等离子体共振来量化二极体chC3d与chCR2的结合亲和力 (KD).
  • 分子对接模拟以确定相互作用模式.

主要成果:

  • C3d (chC3d) 已被证实是二元化的.
  • 模态chC3d表现出与CR2 (chCR2) 的结合,平衡解离常数 (KD) 为827nM.
  • 分子对接显示,二维chC3d可以与chCR2受体进行交叉链接.

结论:

  • C3d (chC3d) 与人类的C3d具有功能上的相似性,包括二元化.
  • 双基chC3d在与chCR2相互作用中发挥作用,可能在中弥合先天性和适应性免疫力.
  • 这些发现为进一步研究补充系统提供了基础.